2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway
  3. EGFR Akt ERK
  4. KU004

KU004 是一种强效的双重 EGFR/HER2 抑制剂，具有抗癌效果。KU004 通过诱导 G1期停滞来抑制人乳腺癌 SKBR3 细胞的增殖。KU004 阻断 HER2，EGFR 及下游 Akt 和 Erk 通路的激活，并主要通过外源性途径诱导细胞凋亡 (Apoptosis)。KU004 是一种新型的喹唑啉衍生物。

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KU004 Chemical Structure

KU004 Chemical Structure

CAS No. : 1260401-93-1

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KU004 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Akt Akt1 Akt2 Akt3

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KU004 is a potent dual EGFR/HER2 inhibitor with anticancer effects. KU004 inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR and downstream Akt and Erk pathways and induces cell Apoptosis mainly via the extrinsic pathway. KU004 is a novel quinazoline derivative[1][2].

分子量

548.98

Formula

C29H27ClFN4O2P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KU004 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KU0041260401-93-1KU 004KU-004EGFRAktERKEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BExtracellular signal regulated kinasesEGFR/HER2anticancer effectsbreast cancerG1 phase arrestErkapoptosisInhibitorinhibitorinhibit

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