2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Endogenous Metabolite GABA Receptor
  4. L-DABA hydrobromide

L-DABA hydrobromide  (Synonyms: L-2,4-二氨基丁酸; L-2,4-Diaminobutyric acid hydrobromide)

目录号: HY-101414A 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

L-DABA (L-2,4-Diaminobutyric acid) hydrobromide 是 GABA 转氨酶的弱抑制剂，IC50 值大于500 μM。在体内和体外具有抗肿瘤活性。

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L-DABA hydrobromide Chemical Structure

L-DABA hydrobromide Chemical Structure

CAS No. : 73143-97-2

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规格 价格 是否有货
100 mg ￥200
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500 mg ￥350
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L-DABA hydrobromide 的其他形式现货产品:

Customer Review

Other Forms of L-DABA hydrobromide:

L-DABA hydrobromide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-DABA (L-2,4-Diaminobutyric acid) hydrobromide is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

IC50 & Target

IC50: larger than 500 μM (GABA transaminase)[1]
体外研究
(In Vitro)

The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA hydrobromide is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA hydrobromide. The harmful effect of L-DABA hydrobromide could be abolished by concomitant incubation with L-alanine and L-methionine[1]. Kinetic studies indicates that L-DABA hydrobromide is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA hydrobromide-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity[2]. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA hydrobromide necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-DABA hydrobromide 相关抗体:
体内研究
(In Vivo)

Treatment with L-DABA hydrobromide results in 43.4% reduction of tumor growth[1]. L-DABA hydrobromide is a more effective inhibitor of GABA transaminase in vivo than in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

199.05

Formula

C4H11BrN2O2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 23 mg/mL (115.55 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.0239 mL 25.1193 mL 50.2386 mL
5 mM 1.0048 mL 5.0239 mL 10.0477 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (168 KB) HNMR (130 KB)

产品使用指南 (1538 KB)
参考文献

L-DABA hydrobromide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.0239 mL 25.1193 mL 50.2386 mL 125.5966 mL
5 mM 1.0048 mL 5.0239 mL 10.0477 mL 25.1193 mL
10 mM 0.5024 mL 2.5119 mL 5.0239 mL 12.5597 mL
15 mM 0.3349 mL 1.6746 mL 3.3492 mL 8.3731 mL
20 mM 0.2512 mL 1.2560 mL 2.5119 mL 6.2798 mL
25 mM 0.2010 mL 1.0048 mL 2.0095 mL 5.0239 mL
30 mM 0.1675 mL 0.8373 mL 1.6746 mL 4.1866 mL
40 mM 0.1256 mL 0.6280 mL 1.2560 mL 3.1399 mL
50 mM 0.1005 mL 0.5024 mL 1.0048 mL 2.5119 mL
60 mM 0.0837 mL 0.4187 mL 0.8373 mL 2.0933 mL
80 mM 0.0628 mL 0.3140 mL 0.6280 mL 1.5700 mL
100 mM 0.0502 mL 0.2512 mL 0.5024 mL 1.2560 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-DABA73143-97-2L-2,4-Diaminobutyric acidEndogenous MetaboliteGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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