2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. L48H37

L48H37 是一种化学稳定性提高了的姜黄素 (HY-N0005) 类似物。L48H37 是一种有效且特异性的髓系分化蛋白 2 (MD2) 抑制剂，抑制 LPS-TLR4/MD2 的相互作用和信号转导。L48H37 用于脓毒症或肺损伤的相关研究。

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L48H37 Chemical Structure

L48H37 Chemical Structure

CAS No. : 343307-76-6

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥851
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5 mg ￥800
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10 mg ￥1200
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25 mg ￥2400
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50 mg ￥3800
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Customer Review

L48H37 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment[1].

IC50 & Target[1]

TLR4

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
4.2 μM
Compound: 7B
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29655083]
HEp-2 IC50
16.59 μM
Compound: 569; CA15
Antiproliferative activity against human HEp-2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human HEp-2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 32172081]
L02 IC50
12.8 μM
Compound: 7B
Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HL7702 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29655083]
L02 IC50
46.79 μM
Compound: 569; CA15
Antiproliferative activity against human HL7702 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human HL7702 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 32172081]
NCI-H1650 IC50
8.2 μM
Compound: 7B
Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H1650 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29655083]
NCI-H1975 IC50
6.5 μM
Compound: 7B
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29655083]
NCI-H460 IC50
4.9 μM
Compound: 7B
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 29655083]
体外研究
(In Vitro)

L48H37 抑制 LPS 诱导的炎症，特别是 TNF-α 和 IL-6 的产生以及小鼠巨噬细胞中的基因表达[1]。
L48H37 (0-20 μM；24 小时) 降低细胞活力A549 和 H460 细胞的 IC50 值分别为 5.3 μM 和 2.3 μM，与肺癌细胞中的姜黄素相比更有效。它对正常人肺上皮细胞 (BEAS-2B) 表现出低细胞毒性，IC50 为 21 μM[2]。
L48H37 (1，2，或 4 μM；16 小时) 剂量依赖性地抑制 p-Cdc2 和 Cdc2 的表达，并增加 p53 的表达。它还显示 H460 和 A549 细胞中裂解聚 (ADP-核糖基) 聚合酶 (PARP) 水平升高和抗凋亡蛋白 Bcl-2 水平降低[2]。
L48H37 (4 μM；16 小时) 通过 H460 和 A549 细胞中增加的 DCF 水平检测到剂量依赖性地快速诱导细胞内 ROS 水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L48H37 相关抗体:

Cell Viability Assay[2]

Cell Line: A549 and H460 cells; BEAS-2B cells
Concentration: 0.625, 1.25, 2.5, 5, 7.5, 10, and 20 µM
Incubation Time: 24 hours
Result: Inhibited lung cancer cells growth in a concentration-dependent manner.

Western Blot Analysis[2]

Cell Line: A549 and H460 cells
Concentration: 0.625, 1.25, 2.5, 5, 7.5, 10, and 20 µM
Incubation Time: 24 hours
Result: Decreased p‐Cdc2, Cdc2, and Bcl‐2 expression in 2 lung cancer cells.
体内研究
(In Vivo)

L48H37 (腹膜内注射；5 mg 或 10 mg/kg；每天一次；11 天) 抑制 H460 异种移植肿瘤的生长，并在小鼠体内表现出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5‐week‐old athymic BALB/cA nu/nu female mice (18‐22 g)[2]
Dosage: 5 mg or 10 mg/kg
Administration: Intraperitoneal injection; once daily; 11‐day
Result: Reduced tumor wet weights as compared to vehicle control.
Decreased the levels of p‐STAT3, and increased the levels of p‐EIF2α and ATF4 in vivo.
Exhibited no significant structural changes in mice.
分子量

483.55

Formula

C27H33NO7
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (103.40 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0680 mL 10.3402 mL 20.6804 mL
5 mM 0.4136 mL 2.0680 mL 4.1361 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

L48H37 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0680 mL 10.3402 mL 20.6804 mL 51.7010 mL
5 mM 0.4136 mL 2.0680 mL 4.1361 mL 10.3402 mL
10 mM 0.2068 mL 1.0340 mL 2.0680 mL 5.1701 mL
15 mM 0.1379 mL 0.6893 mL 1.3787 mL 3.4467 mL
20 mM 0.1034 mL 0.5170 mL 1.0340 mL 2.5850 mL
25 mM 0.0827 mL 0.4136 mL 0.8272 mL 2.0680 mL
30 mM 0.0689 mL 0.3447 mL 0.6893 mL 1.7234 mL
40 mM 0.0517 mL 0.2585 mL 0.5170 mL 1.2925 mL
50 mM 0.0414 mL 0.2068 mL 0.4136 mL 1.0340 mL
60 mM 0.0345 mL 0.1723 mL 0.3447 mL 0.8617 mL
80 mM 0.0259 mL 0.1293 mL 0.2585 mL 0.6463 mL
100 mM 0.0207 mL 0.1034 mL 0.2068 mL 0.5170 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L48H37343307-76-6Toll-like Receptor (TLR)InflammationAsthmalung injurySepsisTLR4/MD2IL-6TNF-αCurcuminInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-126154
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