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  4. Latrunculin B

Latrunculin B  (Synonyms: 红海海绵素 B)

目录号: HY-101848 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Latrunculin B 是一种抗菌生物碱，是一种肌动蛋白聚合 (actin polymerization) 抑制剂。Latrunculin B 调节肺静脉电生理特征并减轻牵张性心律失常的发生。抗真菌和抗原生动物活性。

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Latrunculin B Chemical Structure

Latrunculin B Chemical Structure

CAS No. : 76343-94-7

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规格 价格 是否有货 数量
1 mg ￥4800
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Customer Review

Other Forms of Latrunculin B:

Latrunculin B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
7.1 μM
Compound: 2, NSC-339663
Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
[PMID: 18942825]
HUVEC IC50
478 nM
Compound: LatB
Inhibition of cell migration in human HUVEC cells assessed as decrease in cell velocity measured after 16 hrs by crystal violet staining based scratch assay
Inhibition of cell migration in human HUVEC cells assessed as decrease in cell velocity measured after 16 hrs by crystal violet staining based scratch assay
[PMID: 31260301]
HUVEC IC50
611.6 nM
Compound: LatB
Antiproliferative activity against human HUVEC measured after 72 hrs
Antiproliferative activity against human HUVEC measured after 72 hrs
[PMID: 31260301]
MDA-MB-435 IC50
4.8 μM
Compound: 2, NSC-339663
Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay
[PMID: 18942825]
体外研究
(In Vitro)

Latrunculin B displays growth inhibition of HeLa cells with an IC50 value of 1.4 μM[1].
Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na+ current, L-type Ca2+ current, Na+/Ca2+ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K+ current and ultra-rapid delayed rectifier K+ current, but increases the delayed rectifier K+ current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Latrunculin B 相关抗体:
Clinical Trial
分子量

395.51

Formula

C20H29NO5S
CAS 号
性状

固体

颜色

Colorless to off-white

中文名称

红海海绵素 B
初始来源

Red Sea sponge
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (63.21 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5284 mL 12.6419 mL 25.2838 mL
5 mM 0.5057 mL 2.5284 mL 5.0568 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (292 KB)

产品使用指南 (1538 KB)
参考文献

Latrunculin B 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5284 mL 12.6419 mL 25.2838 mL 63.2095 mL
5 mM 0.5057 mL 2.5284 mL 5.0568 mL 12.6419 mL
10 mM 0.2528 mL 1.2642 mL 2.5284 mL 6.3210 mL
15 mM 0.1686 mL 0.8428 mL 1.6856 mL 4.2140 mL
20 mM 0.1264 mL 0.6321 mL 1.2642 mL 3.1605 mL
25 mM 0.1011 mL 0.5057 mL 1.0114 mL 2.5284 mL
30 mM 0.0843 mL 0.4214 mL 0.8428 mL 2.1070 mL
40 mM 0.0632 mL 0.3160 mL 0.6321 mL 1.5802 mL
50 mM 0.0506 mL 0.2528 mL 0.5057 mL 1.2642 mL
60 mM 0.0421 mL 0.2107 mL 0.4214 mL 1.0535 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Latrunculin B76343-94-7红海海绵素 BFungalantimicrobialmarinealkaloidactinpolymerizationpulmonaryveinelectrophysiologicalstretcharrhythmogenesisInhibitorinhibitorinhibit

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