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  4. Lobaric acid

Lobaric acid是从 Stereocaulon 地衣属植物中分离出来的一种缩酚酸代谢物，具有抗氧化、抗增殖、抗病毒和酶抑制活性。它在无细胞试验中清除超氧化物自由基（IC50=97.9 μmol），并抑制白血病、结直肠癌、胃癌、乳腺癌、卵巢癌、前列腺癌、胰腺癌和肺癌细胞系的增殖（EC50s=15.2-63.9 μg/ml）。2,3 Lobaric acid抑制蛋白酪氨酸磷酸酶 1B（PTP1B；人重组酶的 IC50=0.87 μM）和 12(S)-脂氧合酶产生的 12(S)-HETE（IC50=28.5 μM）。5,6 在体内，Lobaric acid（250 μM）可减少病变数量，在感染烟草花叶病毒 (TMV) 的烟叶中，病变直径没有变化。

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Lobaric acid Chemical Structure

Lobaric acid Chemical Structure

CAS No. : 522-53-2

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Lobaric acid 相关抗体

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生物活性

Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50=97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s=15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for the human recombinant enzyme) and production of 12(S)-HETE by 12(S)-lipoxygenase (IC50=28.5 μM).In vivo, lobaric acid (250 μM) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).

分子量

456.49

Formula

C25H28O8
CAS 号
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Lobaric acid 相关分类

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Keywords:

Lobaric acid522-53-2OthersInhibitorinhibitorinhibit

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