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  4. Lobaric acid

Lobaric acid是从 Stereocaulon 地衣属植物中分离出来的一种缩酚酸代谢物，具有抗氧化、抗增殖、抗病毒和酶抑制活性。它在无细胞试验中清除超氧化物自由基（IC50=97.9 μmol），并抑制白血病、结直肠癌、胃癌、乳腺癌、卵巢癌、前列腺癌、胰腺癌和肺癌细胞系的增殖（EC50s=15.2-63.9 μg/ml）。2,3 Lobaric acid抑制蛋白酪氨酸磷酸酶 1B（PTP1B；人重组酶的 IC50=0.87 μM）和 12(S)-脂氧合酶产生的 12(S)-HETE（IC50=28.5 μM）。5,6 在体内，Lobaric acid（250 μM）可减少病变数量，在感染烟草花叶病毒 (TMV) 的烟叶中，病变直径没有变化。

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Lobaric acid Chemical Structure

Lobaric acid Chemical Structure

CAS No. : 522-53-2

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Lobaric acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50=97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s=15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for the human recombinant enzyme) and production of 12(S)-HETE by 12(S)-lipoxygenase (IC50=28.5 μM).In vivo, lobaric acid (250 μM) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BXPC-3 EC50
1.6 μM
Compound: 4
Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
HCT-116 EC50
0.8 μM
Compound: 4
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
HT-29 EC50
2.39 μM
Compound: Lobaric acid
Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay
Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay
[PMID: 24900447]
HT-29 IC50
4.54 μM
Compound: Lobaric acid
Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
[PMID: 24900447]
J82 EC50
3.6 μM
Compound: 4
Cytotoxicity against human J82 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human J82 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
K562 EC50
1.4 μM
Compound: 4
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
U2OS EC50
17.6 μM
Compound: Lobaric acid
Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay
Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay
[PMID: 24900447]
UMUC3 EC50
3.7 μM
Compound: 4
Cytotoxicity against human UM-UC-3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human UM-UC-3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
分子量

456.49

Formula

C25H28O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lobaric acid 相关分类

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Keywords:

Lobaric acid522-53-2OthersInhibitorinhibitorinhibit

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