2. Metabolic Enzyme/Protease Anti-infection
  3. TMV Phosphatase Lipoxygenase
  4. Lobaric acid

Lobaric acid 是从 Stereocaulon 地衣属植物中分离出来的一种缩酚酸代谢物，具有抗氧化、抗增殖、抗病毒和酶抑制活性。Lobaric acid 能够清除超氧化物自由基（IC50=97.9 μM），并抑制癌细胞的增殖 (对白血病、结直肠癌、胃癌、乳腺癌、卵巢癌、前列腺癌、胰腺癌和肺癌细胞系的 EC50 为 15.2-63.9 μg/mL）。Lobaric acid 抑制蛋白酪氨酸磷酸酶 1B（PTP1B；人重组酶的 IC50=0.87 μM）和 12(S)-脂氧合酶产生的 12(S)-HETE（IC50=28.5 μM）。Lobaric acid（250 μM）还可以减轻感染烟草花叶病毒 (TMV) 的烟叶的病变情况。

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Lobaric acid Chemical Structure

Lobaric acid Chemical Structure

CAS No. : 522-53-2

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Lobaric acid 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 μM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BXPC-3 EC50
1.6 μM
Compound: 4
Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
HCT-116 EC50
0.8 μM
Compound: 4
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
HT-29 EC50
2.39 μM
Compound: Lobaric acid
Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay
Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay
[PMID: 24900447]
HT-29 IC50
4.54 μM
Compound: Lobaric acid
Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
[PMID: 24900447]
J82 EC50
3.6 μM
Compound: 4
Cytotoxicity against human J82 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human J82 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
K562 EC50
1.4 μM
Compound: 4
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
U2OS EC50
17.6 μM
Compound: Lobaric acid
Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay
Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay
[PMID: 24900447]
UMUC3 EC50
3.7 μM
Compound: 4
Cytotoxicity against human UM-UC-3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human UM-UC-3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
[PMID: 27300079]
分子量

456.49

Formula

C25H28O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lobaric acid 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lobaric acid522-53-2TMVPhosphataseLipoxygenaseTobacco mosaic virusLOXInhibitorinhibitorinhibit

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