2. Academic Validation
  3. Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity

  • Arch Pharm Res. 2015;38(5):677-82. doi: 10.1007/s12272-014-0432-3.
Hoang Viet Dung 1,  To Dao Cuong,  Nguyen Minh Chinh,  Do Quyen,  Jeong Ah Kim,  Jeong Su Byeon,  Mi Hee Woo,  Jae Sui Choi,  Byung Sun Min
Affiliations

Affiliation

  • 1 Centre of Pharmaceutical Research-Training, Vietnam Military Medical University, 160 Phung Hung, Hadong, Hanoi, Vietnam.
PMID: 25005067 DOI: 10.1007/s12272-014-0432-3
Abstract

A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.

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