2. Academic Validation
  3. Radical curative activity of a new 8-aminoquinoline derivative (CDRI 80/53) against Plasmodium cynomolgi B in monkeys

Radical curative activity of a new 8-aminoquinoline derivative (CDRI 80/53) against Plasmodium cynomolgi B in monkeys

  • Am J Trop Med Hyg. 1989 Dec;41(6):635-7. doi: 10.4269/ajtmh.1989.41.635.
G P Dutta 1,  S K Puri,  A P Bhaduri,  M Seth
Affiliations

Affiliation

  • 1 Division of Microbiology and Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
PMID: 2641640 DOI: 10.4269/ajtmh.1989.41.635
Abstract

An analogue of primaquine, N1-(3-acetyl-4-5-dihydro-2-furanyl)-N4-(6-methoxy-8-quinolinyl) 1,4-pentanediamine, CDRI Code 80/53), has been evaluated for anti-relapse activity against sporozoite induced Plasmodium cynomolgi B Infection in rhesus monkeys. The compound has shown 100% curative anti-relapse activity at 1.25 mg/kg x 7 day dose schedule, thereby giving a primaquine index of 0.8. The compound is currently under Phase-I clinical trials.

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