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  4. Bulaquine

Bulaquine  (Synonyms: CDRI 80/53; Elubaquine)

目录号: HY-106866
产品使用指南

摩尔计算器

Bulaquine (CDRI 80/53) 是有效的抗疟疾剂，是 Primaquine (HY-12651A) 的类似物。Bulaquine 影响多条代谢途径，对 Plasmodium cynomolgi 感染有抑制作用。Bulaquine 可用于疟疾的研究。

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Bulaquine Chemical Structure

Bulaquine Chemical Structure

CAS No. : 79781-00-3

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Bulaquine 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria[1][2][3].

IC50 & Target

Plasmodium

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7 IC50
10 μM
Compound: 2
Antiplasmodial activity against liver stage Plasmodium berghei infected in Huh7 cells assessed as inhibition of parasite infection incubated for 1 hr prior to infection measured at 24 hrs by luciferase reporter gene assay
Antiplasmodial activity against liver stage Plasmodium berghei infected in Huh7 cells assessed as inhibition of parasite infection incubated for 1 hr prior to infection measured at 24 hrs by luciferase reporter gene assay
[PMID: 26968650]
体内研究
(In Vivo)

Bulaquine (40 mg/kg; p.o. once) affects multiple pathways in vivo[1].
Bulaquine (1.25 mg/kg; once daily; for 7 days) shows 100% curative anti-relapse activity with a primaquine index of 0.8 for rhesus monkeys with Plasmodium cynomolgi B infection[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 25-30 g male Swiss albino mice[1]
Dosage: 40 mg/kg
Administration: Oral gavage; 40 mg/kg once
Result: Affected oxidative stress and fatty acid synthesis pathway, apoptosis, cell cycle, inflammatory response, glycogen metabolism, Kreb’s cycle, electron transport chain, fatty acid β-oxidation, MAPK signalling, signalling of hepatocyte growth factor receptor, matrix metalloproteinases, steroid biosynthesis, TGF-β signalling, translation factors, Wnt signalling, regulation of actin cytoskeleton, ribosomal proteins, RNA transcription reactome, proteasome degradation and nuclear receptors in lipid metabolism according to GO results.
分子量

369.46

Formula

C21H27N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bulaquine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bulaquine79781-00-3CDRI 80/53 ElubaquineParasitemalariainfectionprimaquinePlasmodium cynomolgimiceInhibitorinhibitorinhibit

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