2. Academic Validation
  3. Antidesmone, a unique tetrahydroquinoline alkaloid, prevents acute lung injury via regulating MAPK and NF-κB activities

Antidesmone, a unique tetrahydroquinoline alkaloid, prevents acute lung injury via regulating MAPK and NF-κB activities

  • Int Immunopharmacol. 2017 Apr:45:34-42. doi: 10.1016/j.intimp.2017.01.026.
XinGang Lu 1,  YingXiu Pu 2,  WeiGuang Kong 3,  XiaoDan Tang 4,  JiAn Zhou 4,  HaiXin Gou 1,  Xiao Song 5,  HaiFeng Zhou 6,  NingZhou Gao 6,  Jie Shen 7
Affiliations

Affiliations

  • 1 Department of Traditional Chinese Medicine, HuaDong Hospital, FuDan University, Shanghai 200040, PR China.
  • 2 Department of Anesthesiology, Obstetrics and Gynecology Hospital, FuDan University, Shanghai 200040, PR China.
  • 3 Department of Gastroenterology, Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, Inner Mongolia 010020, PR China.
  • 4 Department of Pulmonary, HuaDong Hospital, FuDan University, Shanghai 200040, PR China.
  • 5 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, PR China.
  • 6 Department of Pharmacy, HuaDong Hospital, FuDan University, Shanghai 200040, PR China.
  • 7 Department of Pharmacy, HuaDong Hospital, FuDan University, Shanghai 200040, PR China. Electronic address: shj421@126.com.
PMID: 28157559 DOI: 10.1016/j.intimp.2017.01.026
Abstract

Acute lung injury, characterized by inflammation, is a main cause of respiratory failure that affects patients worldwide. Antidesmone is one compound mainly isolated from Ajugade cumbens Thunb (Labiatae), an herb agent of Labiatae family. In this research, we investigated the anti-inflammation effect of antidesmone in vitro and in vivo. Antidesmone exerted none apparently cytotoxicity in vitro and toxic in vivo. In vitro results demonstrated that antidesmone suppressed the excess inflammatory cytokines production, including tumor necrosis factor-α, interleukin-6 and interleukin-1β in lipopolysaccharide (LPS)-exposed RAW264.7 cells. In vivo results suggested that antidesmone inhibited inflammatory cytokines in the bronchoalveolar lavage fluid and lung tissue after LPS stimulation. Moreover, antidesmone attenuated the nuclear translocation of p65. Mechanism study revealed that mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways play important roles in antidesmone's action. Taken together, our data uncover a relative toxic anti-inflammatory drug, antidesmone, can inhibit inflammation on stimulated macrophages and thereby prevents acute lung injury by regulating MAPK and NF-κB signaling pathways.

Keywords

Acute lung injury; Antidesmone; MAPK; NF-κB; RAW264.7 cell.

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