2. Academic Validation
  3. Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses

Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses

  • Antimicrob Agents Chemother. 2020 Apr 21;64(5):e00440-20. doi: 10.1128/AAC.00440-20.
Sean Ekins 1,  Peter B Madrid 2
Affiliations

Affiliations

  • 1 Collaborations Pharmaceuticals, Inc., Raleigh, North Carolina, USA sean@collaborationspharma.com peter.madrid@sri.com.
  • 2 SRI International, Menlo Park, California, USA sean@collaborationspharma.com peter.madrid@sri.com.
PMID: 32205350 DOI: 10.1128/AAC.00440-20
Abstract

Tilorone is a 50-year-old synthetic small-molecule compound with Antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum Antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern respiratory syndrome coronavirus (MERS-CoV).

Keywords

antiviral; broad spectrum; emerging viruses.

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