2. Academic Validation
  3. Cardamonin: A new player to fight cancer via multiple cancer signaling pathways

Cardamonin: A new player to fight cancer via multiple cancer signaling pathways

  • Life Sci. 2020 Jun 1;250:117591. doi: 10.1016/j.lfs.2020.117591.
Javaria Nawaz 1,  Azhar Rasul 2,  Muhammad Ajmal Shah 3,  Ghulam Hussain 4,  Ammara Riaz 1,  Iqra Sarfraz 1,  Saba Zafar 1,  Muhammad Adnan 1,  Abdul Haleem Khan 5,  Zeliha Selamoglu 6
Affiliations

Affiliations

  • 1 Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan.
  • 2 Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan. Electronic address: azharrasul@gcuf.edu.pk.
  • 3 Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University Faisalabad 38000, Pakistan. Electronic address: ajmalshah@gcuf.edu.pk.
  • 4 Neurochemical biology and Genetics Laboratory, Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan.
  • 5 Department of Pharmacy, Forman Christian College (A Chartered University), Lahore 54600, Pakistan.
  • 6 Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde, Campus 51240, Turkey.
PMID: 32224026 DOI: 10.1016/j.lfs.2020.117591
Abstract

Nature's pharmacy has undoubtedly served humans as an affordable and safer health-care regime for a long times. Cardamonin, a chalconoid present in several Plants has been known for a longtime to have beneficial properties towards human health. In this review, we aimed to highlight the recent advances achieved in discovering the pharmacological properties of cardamonin. Cardamonin is cardamom-derived chalcone, which plays a role in Cancer treatment, immune system modulation, inflammation and pathogens killing. Through the modulation of cellular signaling pathways, cardamonin activates cell death signal to induce Apoptosis in malignant cells that results in the inhibition of Cancer development. Moreover, cardamonin arrests cell cycle by altering the expression of regulatory proteins during malignant cells division. Due to its relatively selective cytotoxic potential against host malignant cells, cardamonin is emerging as a promising novel experimental Anticancer agent. The potential of cardamonin to target various signaling molecules, transcriptional factors, cytokines and Enzymes, such as mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2 enhances the opportunity to explore it as a new multi-target therapeutic agent. The pharmacokinetic and biosafety profile of cardamonin favor it as a potentially safe biomolecule for pharmaceutical drug development.

Keywords

Anticancer; Cardamom; Cardamonin; Chalcone.

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