2. NF-κB Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis
  4. Cardamonin

Cardamonin  (Synonyms: 豆蔻明; Cardamomin; Alpinetin chalcone)

目录号: HY-N0279 纯度: 98.38%
COA 产品使用指南

摩尔计算器

Cardamonin 是一种黄酮类化合物，并针对各种信号分子、转录因子、细胞因子和酶，可抑制 mTOR、NF-κB、Akt、STAT3、Wnt/β-catenin 和 COX-2，其表现出抗癌、抗炎、抗微生物和抗糖尿病的活性。

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Cardamonin Chemical Structure

Cardamonin Chemical Structure

CAS No. : 18956-16-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥748
In-stock
5 mg ￥680
In-stock
10 mg ￥1160
In-stock
50 mg ￥3500
In-stock
100 mg   询价  
200 mg   询价  

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Customer Review

Other Forms of Cardamonin:

Cardamonin 相关抗体

Top Publications Citing Use of Products

    Cardamonin purchased from MCE. Usage Cited in: Biomed Pharmacother. 2020 Feb;122:109547.  [Abstract]

    Cardamonin promotes the Nrf2-ARE regulated cytoprotective genes in HL-1 cells dependent on Nrf2. western blot analysis were used to determine Nrf2, HO1, NQO1 and GCLM expression levels in HL-1 cells treated with the indicated concentrations of CAR (0, 25, 50 and 100 μM) for 24 h.

    Cardamonin purchased from MCE. Usage Cited in: Biomed Pharmacother. 2020 Feb;122:109547.  [Abstract]

    Cardamonin promotes the Nrf2-ARE regulated cytoprotective genes in HL-1 cells dependent on Nrf2. Western blot analysis of Nrf2, HO1, NQO1 and GCLM.

    查看 NF-κB 亚型特异性产品:

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    查看 STAT 亚型特异性产品:

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    STAT3 STAT5 STAT6 STAT1

    查看 Bcl-2 Family 亚型特异性产品:

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    Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities[1][2].

    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    CCRF-CEM IC50
    ≤ 10 μM
    Compound: 64
    Cytotoxicity in human CCRF-CEM cells by resazurin reduction assay
    Cytotoxicity in human CCRF-CEM cells by resazurin reduction assay
    		[PMID: 28793973]
    DLD-1 IC50
    41.8 μM
    Compound: 6
    Cytotoxicity against human DLD1 cells co-transfected with Sac1 after 24 hrs
    Cytotoxicity against human DLD1 cells co-transfected with Sac1 after 24 hrs
    		[PMID: 19682913]
    L929 IC50
    2 nM
    Compound: PAP-1
    Inhibition of human voltage-gated potassium channel Kv1.3 expressed in L929 cells by whole-cell patch clamp assay
    Inhibition of human voltage-gated potassium channel Kv1.3 expressed in L929 cells by whole-cell patch clamp assay
    		[PMID: 20971642]
    RAW264.7 IC50
    11.48 μM
    Compound: 8a
    Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-induced NO production after 17 to 20 hr by Griess assay
    Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-induced NO production after 17 to 20 hr by Griess assay
    		10.1007/s00044-011-9706-1
    RAW264.7 IC50
    2.2 μM
    Compound: Cardamonin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 12 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 12 hrs by Griess assay
    		[PMID: 28688956]
    RAW264.7 IC50
    2.2 μM
    Compound: Cardamonin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 30 mins followed by LPS challenge measured after 12 hrs by Griess assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 30 mins followed by LPS challenge measured after 12 hrs by Griess assay
    		[PMID: 28011215]
    体外研究
    (In Vitro)

    Cardamonin (5-40 μM, 24 or 48 h) treatment inhibits gastric cancer cell growth[3].
    Cardamonin (10-30 μM, 24 or 48 h) treatment can regulate the expression of apoptosis relative protein[3].
    Cardamonin (10-30 μM, 24 or 48 h) treatment can inhibit STAT3 phosphorylation[3].
    Cardamonin (0-100 μM, 24 h) treatment improves the anti-oxidative capacity in HL-1 cells[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cardamonin 相关抗体:

    Cell Viability Assay[3]

    Cell Line: AGS, MGC-803, BGC-823 cells
    Concentration: 5, 10, 20, 30, 40 μM
    Incubation Time: 24 or 48 hours
    Result: Inhibited cell growth in a concentration-dependent manner.

    Western Blot Analysis[3]

    Cell Line: AGS, MGC-803, BGC-823 cells
    Concentration: 10, 20, 30 μM
    Incubation Time: 24 or 48 hours
    Result: Down-regulated Bcl-2, increased Bax protein expression, and increased the protein expression levels of Caspase-3.

    Western Blot Analysis[3]

    Cell Line: AGS cells
    Concentration: 10, 20, 30 μM
    Incubation Time: 24 or 48 hours
    Result: Suppressed the phosphorylation level of STAT3.

    Western Blot Analysis[4]

    Cell Line: HL-1 cells
    Concentration: 0, 25, 50, 100 μM
    Incubation Time: 24 hours
    Result: Showed anti-oxidant effects in doxorubicin-stimulated cardiomyocytes.
    体内研究
    (In Vivo)

    Cardamonin (oral gavage; 20, 40 or 80 mg/kg; once) treatments alleviates doxorubicin-induced cardiotoxicity and inhibits apoptosis in doxorubicin-challenged mice[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 J mice (8 weeks old, 20-22 g)[4]
    Dosage: 20, 40 or 80 mg/kg
    Administration: Oral gavage; 20, 40 or 80 mg/kg; once
    Result: Rescued the reduction of LVEF% and LVFS% by doxorubicin, reduced the increasement of serum LDH, CK-MB and Tn-T levels by doxorubicin in a dose-dependent manner, improved doxorubicin-induced histological changes, and attenuated collagen accumulation in cardiac sections by doxorubicin in a dose-dependent manner.
    Animal Model: Male C57BL/6 J mice (8 weeks old, 20-22 g)[4]
    Dosage: 20, 40 or 80 mg/kg
    Administration: Oral gavage; 20, 40 or 80 mg/kg; once
    Result: Rescued Bcl-2, and inhibited Bax and Caspase-3 cleavage in heart tissues from doxorubicin-challenged mice.
    分子量

    270.28

    Formula

    C16H14O4
    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    中文名称

    豆蔻明；豆蔻素；豆寇明
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 125 mg/mL (462.48 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.6999 mL 18.4993 mL 36.9987 mL
    5 mM 0.7400 mL 3.6999 mL 7.3997 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    请根据您的 实验动物和给药方式 选择适当的溶解方案。

    以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
    以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 方案 一

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.17 mg/mL (8.03 mM); 澄清溶液

      此方案可获得 ≥ 2.17 mg/mL（饱和度未知）的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 21.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

      生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    请输入您的动物体内配方组成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
    方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
    计算结果
    工作液所需浓度 : mg/mL
    储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
    您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
    动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
    连续给药周期超过半月以上，请谨慎选择该方案。
    请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
    纯度 & 产品资料

    纯度: 98.38%

    COA (192 KB) LCMS (93 KB)

    产品使用指南 (1538 KB)
    参考文献

    Cardamonin 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.6999 mL 18.4993 mL 36.9987 mL 92.4967 mL
    5 mM 0.7400 mL 3.6999 mL 7.3997 mL 18.4993 mL
    10 mM 0.3700 mL 1.8499 mL 3.6999 mL 9.2497 mL
    15 mM 0.2467 mL 1.2333 mL 2.4666 mL 6.1664 mL
    20 mM 0.1850 mL 0.9250 mL 1.8499 mL 4.6248 mL
    25 mM 0.1480 mL 0.7400 mL 1.4799 mL 3.6999 mL
    30 mM 0.1233 mL 0.6166 mL 1.2333 mL 3.0832 mL
    40 mM 0.0925 mL 0.4625 mL 0.9250 mL 2.3124 mL
    50 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8499 mL
    60 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5416 mL
    80 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
    100 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9250 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cardamonin18956-16-6Cardamomin Alpinetin chalcone豆蔻明豆蔻素豆寇明NF-κBSTATWntβ-cateninBcl-2 FamilyApoptosisNuclear factor-κBNuclear factor-kappaBBeta cateninanticancer activityanti-inflammatory activityantimicrobial activityantidiabetic activityAGSMGC-803BGC-823HL-1Inhibitorinhibitorinhibit

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