2. Academic Validation
  3. Flavonoids from Sophora alopecuroides L. improve palmitate-induced insulin resistance by inhibiting PTP1B activity in vitro

Flavonoids from Sophora alopecuroides L. improve palmitate-induced insulin resistance by inhibiting PTP1B activity in vitro

  • Bioorg Med Chem Lett. 2021 Mar 1:35:127775. doi: 10.1016/j.bmcl.2021.127775.
Ming Zhang 1,  Yuwei Zhang 2,  Qiqi Huang 1,  Hui Duan 1,  Guodong Zhao 1,  Lei Liu 3,  Yuxin Li 4
Affiliations

Affiliations

  • 1 National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China.
  • 2 Chinese Medicine Research Institute, Shandong Hongjitang Pharmaceutical Group Co., Ltd., Jinan 250103, China.
  • 3 National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: liul905@nenu.edu.cn.
  • 4 National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: liyx486@nenu.edu.cn.
PMID: 33412152 DOI: 10.1016/j.bmcl.2021.127775
Abstract

Seventeen Flavonoids (1-17) were isolated from Sophora alopecuroides L.. Compounds 1 and 2 were new compounds, and compounds 5, 8, 11, 12, and 17 were isolated from S. alopecuroides for the first time. The sources of compounds 1 and 2 were determined from the seeds of S. alopecuroides by UPLC-QE-Orbitrap-MS, and compounds 1, 2, 7, 13, 14, 15, 16, and 17 were proven to improve the Insulin resistance of C2C12 myotubes and significantly increase glucose consumption levels. Among them, compounds 1, 2, 13, 14, 16, and 17 could bind to protein tyrosine Phosphatase 1B (PTP1B), thereby significantly inhibiting the Enzyme activity of PTP1B. Compound 2 had the strongest inhibitory effect, with an inhibition rate of 95.22% at 0.1 μg mL-1.

Keywords

Flavonoids; Insulin resistance; Leguminosae; PTP1B; Sophora alopecuroides L..

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