Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

Affiliations

• 1 Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
• 2 New York Stem Cell Foundation Research Institute, New York, NY, USA.
• 3 Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
• 4 Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
• 5 Center for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for the Study of Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
• 6 Department of Biochemistry, Emory School of Medicine, Atlanta, GA, USA.
• 7 Department of Neurology, Emory School of Medicine, Atlanta, GA, USA.
• 8 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• 9 Department of Biochemistry, Emory School of Medicine, Atlanta, GA, USA; Department of Neurology, Emory School of Medicine, Atlanta, GA, USA.
• 10 Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Electronic address: tpearse@bwh.harvard.edu.