2. Metabolic Enzyme/Protease Apoptosis Autophagy
  3. Phosphatase Mitochondrial Metabolism Apoptosis Autophagy
  4. C2 Ceramide

C2 Ceramide  (Synonyms: N-乙酰基神经鞘氨醇; Ceramide 2)

目录号: HY-101180 纯度: 99.85%
COA 产品使用指南

摩尔计算器

C2 Ceramide (Ceramide 2) 是一种角质层的主要脂质，也是一种蛋白质磷酸酶 1 (PP1) 的激活剂。C2 Ceramide 还可激活 PP2A 和神经酰胺激活的蛋白磷酸酶 (CAPP)。C2 Ceramide 可诱导细胞分，自噬 autophagy 和凋亡 (apoptosis)，抑制线粒体呼吸链复合物 III (mitochondrial respiratory chain complex III)。C2 Ceramide 是一种皮肤调理剂，可保护表皮屏障免受水分流失。

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C2 Ceramide Chemical Structure

C2 Ceramide Chemical Structure

CAS No. : 3102-57-6

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规格 价格 是否有货 数量
1 mg ￥400
In-stock
5 mg ￥1400
In-stock
10 mg ￥2170
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

C2 Ceramide 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss[1][2][3][4][5].

IC50 & Target

Protein phosphatase 1[2]
PP2A[4]
Ceramide-activated protein phosphatase (CAPP)[4]
Apoptosis[1]
Mitochondrial respiratory chain complex III[1]
体外研究
(In Vitro)

C2 Ceramide (5 nM-200 µM; 24 hours; primary mouse osteoblasts) treatment (≤500 nM) promots osteoblast viability, whilst concentrations ≥2 µM significantly reduces osteoblast viability in a dose- and time-dependent manner[1].
C2 Ceramide increases cytoplasmic histone-associated DNA fragments by 5.7- and 11.2-fold at 50 µM and 100 µM C2 Ceramide concentrations respectively in osteoblasts. At these higher concentrations, C2 Ceramide is a potent inducer of apoptosis in osteoblasts[1].
C2 Ceramide up-regulates mRNA expression of angiogenic genes in human dental pulp cells (HDPCs) and increases the migration and capillary tube formation of endothelial cells, whereas PP1 small interfering RNA shows opposite effects. Human dental pulp cells (HDPCs) increases levels of bone morphogenetic protein 2, phosphorylation of Smad 1/5/8, and mRNA expression of runt-related transcription factor 2 and osterix[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C2 Ceramide 相关抗体:

Cell Viability Assay[1]

Cell Line: Primary mouse osteoblasts
Concentration: 5 nM-200 µM
Incubation Time: 24 hours
Result: Murine osteoblasts demonstrated a dose-dependent increase in their survival rate when exposed to low concentrations of 5-500 n M. Increasing concentrations of 20-200µM caused a dose-dependent decrease in mitochondrial succinate dehydrogenase activity and osteoblast survival.
体内研究
(In Vivo)

The PP1 activator C2 Ceramide increases alkaline phosphatase activity, mineralizes nodule formation, and mRNA expression of dentin matrix protein 1 and dentin sialophosphoprotein. In contrast, knockdown by PP1 small interfering RNA inhibits odontoblastic differentiation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

341.53

Formula

C20H39NO3
CAS 号
性状

固体

颜色

White to off-white

中文名称

N-乙酰基神经鞘氨醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 20 mg/mL (58.56 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

Ethanol 中的溶解度 : 17 mg/mL (49.78 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9280 mL 14.6400 mL 29.2800 mL
5 mM 0.5856 mL 2.9280 mL 5.8560 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.85%

COA (185 KB) HNMR (279 KB) RP-HPLC (241 KB) MS (70 KB)

产品使用指南 (1538 KB)
参考文献

C2 Ceramide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.9280 mL 14.6400 mL 29.2800 mL 73.2000 mL
5 mM 0.5856 mL 2.9280 mL 5.8560 mL 14.6400 mL
10 mM 0.2928 mL 1.4640 mL 2.9280 mL 7.3200 mL
15 mM 0.1952 mL 0.9760 mL 1.9520 mL 4.8800 mL
20 mM 0.1464 mL 0.7320 mL 1.4640 mL 3.6600 mL
25 mM 0.1171 mL 0.5856 mL 1.1712 mL 2.9280 mL
30 mM 0.0976 mL 0.4880 mL 0.9760 mL 2.4400 mL
40 mM 0.0732 mL 0.3660 mL 0.7320 mL 1.8300 mL
DMSO 50 mM 0.0586 mL 0.2928 mL 0.5856 mL 1.4640 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C2 Ceramide3102-57-6Ceramide 2N-乙酰基神经鞘氨醇Ceramide2Ceramide-2PhosphataseMitochondrial MetabolismApoptosisAutophagySkinpenetrationlipidceramidesdentalPP1angiogenesisdifferentiationmitochondrialrespiratoryPP2ACAPPInhibitorinhibitorinhibit

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目录号：
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