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  3. Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin

Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin

  • J Virol Methods. 2021 Dec;298:114283. doi: 10.1016/j.jviromet.2021.114283.
Martina Mravinec 1,  Gregor Bajc 1,  Matej Butala 2
Affiliations

Affiliations

  • 1 Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana 1000, Slovenia.
  • 2 Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana 1000, Slovenia. Electronic address: matej.butala@bf.uni-lj.si.
PMID: 34534610 DOI: 10.1016/j.jviromet.2021.114283
Abstract

The SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is essential for virus replication, therefore it is a promising drug target. Here we present a surface plasmon resonance approach to study the interaction of RdRp with drugs in real time. We monitored the effect of favipiravir, ribavirin, sofosbuvir triphosphate PSI-7409 and suramin on RdRp binding to RNA immobilized on the chip. Suramin precluded interaction of RdRp with RNA and even displaced RdRp from RNA.

Keywords

RNA-dependent RNA polymerase; SARS-CoV-2; Suramin; Surface plasmon resonance.

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