2. Academic Validation
  3. Scoparone induces autophagic cell death via the PAK1/AKT axis in colorectal cancer

Scoparone induces autophagic cell death via the PAK1/AKT axis in colorectal cancer

  • Eur J Pharmacol. 2023 Oct 5:176091. doi: 10.1016/j.ejphar.2023.176091.
Sha Huang 1,  Luping Lin 1,  Yifei Ma 2,  Qing Zhu 3,  Ningna Weng 4
Affiliations

Affiliations

  • 1 Department of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fujian, 350011, PR China; Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fujian, 350011, PR China.
  • 2 Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, 610041, China.
  • 3 Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address: zhuqing197202@163.com.
  • 4 Department of Medical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fujian, 350011, PR China; Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fujian, 350011, PR China; Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address: nancywengningna@163.com.
PMID: 37805132 DOI: 10.1016/j.ejphar.2023.176091
Abstract

Colorectal Cancer (CRC) is one of most common malignancies worldwide, yet curative therapy remains a clinical challenge. Here, we demonstrate that scoparone (Scop), a traditional Chinese medicine monomer, inhibits the growth of CRC cells both in vitro and in vivo. Further studies found that Scop treatment induces complete autophagic flux in CRC cells, while inhibition of Autophagy markedly represses the antiproliferative activities of Scop, suggesting an antitumour property of Scop-induced Autophagy in CRC. Mechanistically, Scop induced Autophagy initiation by reducing p21-Activated Kinase 1 (PAK1) expression and subsequently repressing the Akt/mTOR signaling pathway. Collectively, our study suggests that Scop is a potential anti-CRC therapeutic option and provides an underlying molecular mechanism for its antitumour effect in CRC.

Keywords

AKT; Autophagy; Colorectal cancer; PAK1; Scoparone.

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