EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma

Affiliations

• 1 UPMC Hillman Cancer Center and Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
• 2 Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
• 3 Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH 44195, USA.
• 4 Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
• 5 Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
• 6 Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
• 7 School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
• 8 Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, Zhejiang 310024, China.
• 9 Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
• 10 Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA.
• 11 Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.
• 12 UPMC Hillman Cancer Center and Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: drjeremyrich@gmail.com.