2. Signaling Pathways
  3. YTHDF

YTHDF 

(YTH) domain-containing family proteins (YTHDF)

(YTH) domain-containing family proteins (YTHDFs) are a class of cytoplasmic m6A-binding proteins characterized by the vertebrate YTH domain, which enables them to regulate RNA fate extensively. The YTH domain serves as the basis for specific recognition of m6A-modified RNA. As the most studied "readers" of m6A, the YTHDF family includes YTHDF1, YTHDF2, and YTHDF3. YTHDF1 promotes RNA translation, while YTHDF2 facilitates RNA decay. YTHDF3 exhibits a dual function that depends on its binding partner. Upon entering the cytoplasm, m6A-modified mRNAs are initially bound by YTHDF3 or a YTHDF3-YTHDF1 complex, followed by recognition by YTHDF2, thereby directing the diverse fates of the targeted mRNA. The YTHDF family plays a significant role in mediating tumor proliferation, metastasis, metabolism, drug resistance, and immunity. Moreover, they possess potential as predictive and therapeutic biomarkers[1].

YTHDF 亚型特异性产品:

YTHDF Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154919
    DC-Y13-27 Inhibitor 99.52%
    DC-Y13-27，DC-Y13 的衍生物，是一种 YTHDF2 抑制剂 (KD: 37.9 μM)。DC-Y13-27 增强肿瘤对放疗和免疫疗法的响应。
    DC-Y13-27
  • HY-RS15938
    YTHDF2 Human Pre-designed siRNA Set A Inhibitor
    YTHDF2 Human Pre-designed siRNA Set A 包括针对 YTHDF2 (Human) 基因的不同区域设计三对 siRNA，以及阴性对照、FAM 标记阴性对照和阳性对照。
    YTHDF2 Human Pre-designed siRNA Set A
    YTHDF2 Human Pre-designed siRNA Set A
  • HY-RS15939
    YTHDF3 Human Pre-designed siRNA Set A Inhibitor
    YTHDF3 Human Pre-designed siRNA Set A 包括针对 YTHDF3 (Human) 基因的不同区域设计三对 siRNA，以及阴性对照、FAM 标记阴性对照和阳性对照。
    YTHDF3 Human Pre-designed siRNA Set A
    YTHDF3 Human Pre-designed siRNA Set A
  • HY-RS15937
    YTHDF1 Human Pre-designed siRNA Set A Inhibitor
    YTHDF1 Human Pre-designed siRNA Set A 包括针对 YTHDF1 (Human) 基因的不同区域设计三对 siRNA，以及阴性对照、FAM 标记阴性对照和阳性对照。
    YTHDF1 Human Pre-designed siRNA Set A
    YTHDF1 Human Pre-designed siRNA Set A
  • HY-173008
    YTHDF2-IN-1 Inhibitor
    YTHDF2-IN-1 (Compound CK-75) 是 YT521-B 同源域家族 2 YTHDF2 的抑制剂（Kd=26.2 μM），可阻断 YTHDF2 与 m6A RNA 之间的相互作用。YTHDF2-IN-1 可抑制 JAR 细胞的集落形成，在多种癌细胞中表现出抗增殖活性（IC50 为微摩尔水平），在 G0/G1 期阻滞细胞周期，诱导 K562 细胞凋亡 (apoptosis)。
    YTHDF2-IN-1
  • HY-168610
    YTH-IN-1 Inhibitor
    YTH-IN-1 (compound N-7) 是一种泛 YTH 结构域抑制剂，对人 YTHYTHDF1、YTHYTHDF2、YTHYTHDF3、YTHYTHDC1 和 YTHYTHDC2 的 IC50 值分别为 39 μM、34 μM、35 μM、48 μM 和 30 μM。
    YTH-IN-1
YTHDF Isoform Comparison

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