2. Academic Validation
  3. Dual-functional gallium/chitosan/silk/umbilical cord mesenchymal stem cell exosome sponge scaffold for diabetic wound by angiogenesis and antibacteria

Dual-functional gallium/chitosan/silk/umbilical cord mesenchymal stem cell exosome sponge scaffold for diabetic wound by angiogenesis and antibacteria

  • Int J Biol Macromol. 2024 Aug;274(Pt 2):133420. doi: 10.1016/j.ijbiomac.2024.133420.
Xin Shi 1,  Yabei Li 2,  Simiao Kang 3,  Xin Zhao 4,  Liang Liu 2,  Feifei Yuan 5,  Liyun He 6,  Hongbin Lu 7,  Jun Liu 8
Affiliations

Affiliations

  • 1 Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China; Hunan Engineering Research Center of Sports and Health, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
  • 2 Department of Limbs (Foot and Hand) Microsurgery, Chenzhou No.1 People's Hospital, Chenzhou, China; The First School of Clinical Medicine, Xiangnan University, Chenzhou, China.
  • 3 Department of Sports Medicine and Joint Arthroplasty, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
  • 4 Department of Limbs (Foot and Hand) Microsurgery, Chenzhou No.1 People's Hospital, Chenzhou, China; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; The First School of Clinical Medicine, Xiangnan University, Chenzhou, China.
  • 5 Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China; Hunan Engineering Research Center of Sports and Health, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
  • 6 Department of Health Management Center, Chenzhou No.1 People's Hospital, Chenzhou, China. Electronic address: 2332376810@qq.com.
  • 7 Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China; Hunan Engineering Research Center of Sports and Health, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: hongbinlu@hotmail.com.
  • 8 Department of Limbs (Foot and Hand) Microsurgery, Chenzhou No.1 People's Hospital, Chenzhou, China; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; The First School of Clinical Medicine, Xiangnan University, Chenzhou, China. Electronic address: liujunheliyun@163.com.
PMID: 38925194 DOI: 10.1016/j.ijbiomac.2024.133420
Abstract

The treatment of diabetic wounds possessed significant challenges in clinical practice, which was accompanied with continuous Infection, inflammation, and limited angiogenesis. Current wound dressings used for diabetic wound healing struggle to address these issues simultaneously. Therefore, Ga3+ was added to the chitosan/silk solution to confer potent Antibacterial properties. Subsequently, umbilical cord mesenchymal stem cell exosomes (UCSC-Exo) were integrated into the gallium/chitosan/silk solution to enhance its angiogenesis-inducing activity. The mixture was lyophilized to prepare gallium/chitosan/silk/exosome Sponge scaffolds (Ga/CSSF-Exo Sponge scaffolds). The experiments of In vitro and in vivo demonstrated that Ga/CSSF-Exo Sponge scaffolds exhibited sustained release of Ga3+ and bioactive exosomes, which effectively exerted continuous Antibacterial effects and promoted angiogenesis. In diabetic rat wound models, Ga/CSSF-Exo Sponge scaffolds facilitated angiogenesis, suppressed Bacterial growth and inflammation, as well as promoted collagen deposition and re-epithelialization of wounds. Collectively, our findings suggested that Ga/CSSF-Exo held excellent potential for diabetic wound healing.

Keywords

Diabetic wound healing; Silk/chitosan/gallium; Umbilical cord mesenchymal stem cell exosome.

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