2. Academic Validation
  3. Adiponectin receptor 1-mediated basolateral amygdala-prelimbic cortex circuit regulates methamphetamine-associated memory

Adiponectin receptor 1-mediated basolateral amygdala-prelimbic cortex circuit regulates methamphetamine-associated memory

  • Cell Rep. 2024 Dec 24;43(12):115074. doi: 10.1016/j.celrep.2024.115074.
Zhigang Chen 1,  Susu Tang 1,  Xiangyi Xiao 2,  Yizhou Hong 3,  Boli Fu 1,  Xuyi Li 1,  Yuwei Shao 1,  Liang Chen 1,  Danhua Yuan 1,  Yan Long 4,  Hao Wang 5,  Hao Hong 6
Affiliations

Affiliations

  • 1 College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • 2 School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • 3 Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • 4 College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: long7027610@163.com.
  • 5 Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine/Nanhu Brain-computer Interface Institute, Hangzhou 310013, China. Electronic address: wanghao890625@126.com.
  • 6 College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: honghao@cpu.edu.cn.
PMID: 39661515 DOI: 10.1016/j.celrep.2024.115074
Abstract

The association between drug-induced rewards and environmental cues represents a promising strategy to address addiction. However, the neural networks and molecular mechanisms orchestrating methamphetamine (MA)-associated memories remain incompletely characterized. In this study, we demonstrated that AdipoRon (AR), a specific Adiponectin Receptor (AdipoR) agonist, inhibits the formation of MA-induced conditioned place preference (CPP) in MA-conditioned mice, accompanied by suppression of basolateral amygdala (BLA) CaMKIIα neuron activity. Furthermore, we identified an association between the excitatory circuit from the BLA to the prelimbic cortex (PrL) and the integration of MA-induced rewards with environmental cues. We also determined that the phosphorylated AMPK (p-AMPK)/Cav1.3 signaling pathway mediates the modulatory effects of AdipoR1 in PrL-projecting BLA CaMKIIα neurons on the formation of MA reward memories, a process influenced by physical exercise. These findings highlight the critical function of AdipoR1 in the BLACaMKIIα→PrLCaMKIIα circuit in regulating MA-related memory formation, suggesting a potential target for managing MA use disorders.

Keywords

AdipoR1; CP: Molecular biology; CP: Neuroscience; basolateral amygdala; methamphetamine; prefrontal cortex; reward memory.

Figures
Products
Inhibitors & Agonists
Other Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z