2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. MEN 10207

MEN 10207 是一种选择性 NK-2 (Neurokinin Receptor) 速激肽受体拮抗剂。MEN 10207 在 NK-1、NK-2 和 NK-3 速激肽受体的三种单受体体外测定中的 pA2 值分别为 5.2、7.9 和 4.9。

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Custom Peptide Synthesis

MEN 10207 Chemical Structure

MEN 10207 Chemical Structure

CAS No. : 126050-12-2

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规格 价格 是否有货 数量
1 mg ￥350
In-stock
5 mg ￥850
In-stock
10 mg ￥1300
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

MEN 10207 相关抗体

Top Publications Citing Use of Products

查看 Neurokinin Receptor 亚型特异性产品:

查看所有亚型
NK1 NK2 NK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

IC50 & Target[2]

Tachykinin NK2 Receptor

7.9 (pA2)

NK1

5.2 (pA2)

NK3

4.9 (pA2)

体外研究
(In Vitro)

In competitive radioligand binding assays, MEN 10207 (the IC50 ranges of 21-54 nM) has high affinity in bovine stomach membranes and SKLKB82#3 cells, a murine fibroblast cell line transfected with a cDNA encoding for the bovine NK2 receptor[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MEN 10207 相关抗体:
体内研究
(In Vivo)

but not Substance P in a dose-dependent manner. And MEN 10207 also effectively blocks the long-term reflex facilitation to the gastrocnemius nerve stimulation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Decerebrate, spinalized, unanesthetized Female Sprague-Dawley rats (250-280 g)[1]
Dosage: 7 pmol/10 μL, 70 pmol/10 μL, 700 pmol/10 μL
Administration: Intrathecal administration; once
Result: Blocked the reflex facilitation to intrathecal Neurokinin A, but not Substance P in a dose-dependent manner.
分子量

1109.24

Formula

C57H68N14O10
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (45.08 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9015 mL 4.5076 mL 9.0152 mL
5 mM 0.1803 mL 0.9015 mL 1.8030 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MEN 10207 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9015 mL 4.5076 mL 9.0152 mL 22.5380 mL
5 mM 0.1803 mL 0.9015 mL 1.8030 mL 4.5076 mL
10 mM 0.0902 mL 0.4508 mL 0.9015 mL 2.2538 mL
15 mM 0.0601 mL 0.3005 mL 0.6010 mL 1.5025 mL
20 mM 0.0451 mL 0.2254 mL 0.4508 mL 1.1269 mL
25 mM 0.0361 mL 0.1803 mL 0.3606 mL 0.9015 mL
30 mM 0.0301 mL 0.1503 mL 0.3005 mL 0.7513 mL
40 mM 0.0225 mL 0.1127 mL 0.2254 mL 0.5634 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEN 10207126050-12-2MEN10207MEN-10207Neurokinin ReceptorNK receptorTachykinin receptorNK-2 tachykinin receptor antagonistselectiveNeurokinin AInhibitorinhibitorinhibit

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产品名称：
MEN 10207
目录号：
HY-151413
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