Mephenesin-d₃  (Synonyms: 甲酚甘油醚-d₃)

Mephenesin-d₃ is deuterium labeled Mephenesin. Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm^{[1][2][3][4][5][6]}.

185.23

C₁₀H₁₁D₃O₃

59-47-2

麦酚生-d₃；马佛生-d₃；美芬新-d₃；甲苯丙醇-d₃；甲酚甘油醚-d₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Crankshaw DP, et al. Mephenesin, methocarbamol, chlordiazepoxide and diazepam: actions on spinal reflexes and ventral root potentials. Br J Pharmacol. 1970 Jan;38(1):148-56.  [Content Brief]

  [3]. Mephenesin: abuse and dependence. Prescrire Int. 2013 May;22(138):127-128.  [Content Brief]

  [4]. Ludwig B J, et al. Muscle-paralyzing compounds related to mephenesin[J]. Journal of the American Chemical Society, 1952, 74(8): 1935-1939.

  [5]. ?cija P, et al. Conformational flexibility of mephenesin. J Phys Chem B. 2014 May 22;118(20):5357-5364.  [Content Brief]

  [6]. DIAZ-RIVERA RS, et al. Muscular relaxation in tetanus with special reference to the effect of mephenesin. Ann Intern Med. 1954 Mar;40(3):563-80.  [Content Brief]