2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Mexiletine

Mexiletine  (Synonyms: 美西律; KOE-1173)

目录号: HY-119521
产品使用指南

摩尔计算器

Mexiletine 是一种口服有效的抗心律失常剂，也被发现对肌强直和神经病理性疼痛有效。Mexiletine 通过阻断钠离子通道 (IC50 : 75±8 μM 于封闭性阻断, 23.6±2.8 μM 于使用依赖性阻断) 发挥作用，可被用于心血管与神经病学研究。

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Mexiletine Chemical Structure

Mexiletine Chemical Structure

CAS No. : 31828-71-4

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Mexiletine 的其他形式现货产品:

Other Forms of Mexiletine:

Mexiletine 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research[1][2][3][4][5].

IC50 & Target

IC50: 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block (sodium channel of HEK293 transfected with hNav1.5 plasmid)[2]
体外研究
(In Vitro)

Mexiletine (10µM, 48 h) 在转染 SCN5A-WT 或 SCN5A-1795insD 的 HEK293A 细胞中增加了峰值 INa 和晚期 INa，Mexiletine (10µM, 5 min) 阻断了晚期 INa[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mexiletine 相关抗体:
体内研究
(In Vivo)

Mexiletine (30, 100 mg/kg, 口服, 急性给药) 逆转 Oxaliplatin (HY-17371) 诱导的大鼠机械痛觉过敏和低温痛觉过敏[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats with Oxaliplatin (HY-17371)-induced neuropathic pain [4]
Dosage: Oxaliplatin (4 mg /kg) and Mexiletine(10, 30, 100 mg/kg)
Administration: Oxaliplatin, Intraperitoneal injection (i.p.)in days 1, 2, 8, 9, 15, 16, 22, and 23; Mexiletine, Oral gavage (p.o.), acute administration
Result: 100 mg/kg completely reversed the reduction of 50% paw withdrawal threshold by Oxaliplatin at 60 min after administration in the von Frey test, completely reversed the increase of number of withdrawal responses at 60 and 120 min after administration in the acetone test.
30 mg/kg partly reversed the symptom and 10 mg/kg did not reverse any symptom. The effect disappeared by 180 min after administration.
分子量

179.26

Formula

C11H17NO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    PBS

  • 方案 二

    10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline

  • 方案 三

    10% DMSO + 90% (20% SBE-β-CD in saline)

  • 方案 四

    10% DMSO + 90% corn oil

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Mexiletine 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mexiletine31828-71-4KOE-1173KOE1173KOE 1173Sodium ChannelNa channelsNa+ channelsantiarrhythmic agentmyotonianeuropathic painsodium channelcardiovascularneurologicalHEK293AhiPSC-CMsSprague-Dawley ratsInhibitorinhibitorinhibit

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目录号：
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