2. Anti-infection
  3. Parasite
  4. Milbemycin A4 oxime

Milbemycin A4 oxime  (Synonyms: 5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime)

目录号: HY-138074
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Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) 是 Milbemycin A4 (HY-126906) 的衍生物，也是 Milbemycin oxime (HY-B0778) 的成分，这两种化合物都具有杀虫和杀线虫活性。Milbemycin A4 oxime (0.05 mg/kg) 可减少自然感染犬心丝虫 D. immitis 的微丝蚴数量，抑制光滑念珠菌临床分离株的生长 (MIC80=16-32 μg/mL)。Milbemycin A4 oxime (2.5 μg/mL) 可阻断 Fluconazole (HY-B0101) 从光滑念珠菌临床分离株中流出。Milbemycin A4 oxime 能增强阿霉素诱导的细胞生长抑制作用，并以浓度依赖性方式增加阿霉素耐药但不敏感的 MCF-7 乳腺癌细胞中阿霉素和 P-糖蛋白底物 Rhodamine 123 (HY-D0816) 的细胞内积累。

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Milbemycin A4 oxime Chemical Structure

Milbemycin A4 oxime Chemical Structure

CAS No. : 93074-04-5

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规格 价格 是否有货 数量
1 mg ￥3000
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

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Milbemycin A4 oxime 相关抗体

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  • 生物活性

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生物活性

Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) is a derivative of Milbemycin A4 (HY-126906) and a component of Milbemycin oxime (HY-B0778), both of which have insecticidal and nematicidal activities. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae in naturally infected dogs with D. immitis and inhibits the growth of clinical isolates of Candida glabrata (MIC80=16-32 μg/mL). Milbemycin A4 oxime (2.5 μg/mL) blocks the efflux of Fluconazole (HY-B0101) from clinical isolates of Candida glabrata. Milbemycin A4 oxime enhances doxorubicin-induced cell growth inhibition and increases the intracellular accumulation of doxorubicin and P-glycoprotein substrate Rhodamine 123 (HY-D0816) in doxorubicin-resistant but not sensitive MCF-7 breast cancer cells in a concentration-dependent manner.

分子量

555.70

Formula

C32H45NO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Milbemycin A4 oxime 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Milbemycin A4 oxime93074-04-55-Ketomilbemycin A4 oxime 5-Oxomilbemycin A4 5-oximeParasiteInhibitorinhibitorinhibit

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