2. Anti-infection
  3. Parasite
  4. Milbemycin A4 oxime

Milbemycin A4 oxime  (Synonyms: 5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime)

目录号: HY-138074
产品使用指南

摩尔计算器

Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime)是米尔贝霉素 A4 的衍生物，也是米尔贝霉素肟 (HY-B0778) 的成分，这两种化合物都具有杀虫和杀线虫活性。Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) (0.05 mg/kg) 可减少自然感染犬心丝虫 D. immitis 的微丝蚴数量。它可抑制光滑念珠菌临床分离株的生长，MIC80 值范围为 16 至 32 μg/mL 以上。Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) (2.5 μg/mL) 可阻断 Fluconazole (HY-B0101) 从光滑念珠菌临床分离株中流出，但不能阻断缺乏流出泵 CgCDR1 和 PDH1 的菌株的流出，并降低野生型光滑念珠菌中氟康唑和 4-硝基喹啉 1-氧化物的 MIC。它能增强阿霉素诱导的细胞生长抑制作用，并以浓度依赖性方式增加阿霉素耐药但不敏感的 MCF-7 乳腺癌细胞中阿霉素和 P-糖蛋白底物 Rhodamine 123 (HY-D0816) 的细胞内积累。

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Milbemycin A4 oxime Chemical Structure

Milbemycin A4 oxime Chemical Structure

CAS No. : 93074-04-5

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规格 价格 是否有货 数量
1 mg ￥3000
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

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Milbemycin A4 oxime 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Milbemycin A4 oxime is a derivative of milbemycin A4 (Item No. 17155) and a component of Milbemycin Oxime (HY-B0778), compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs. It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/mL.1 Milbemycin A4 oxime (2.5 μg/mL) blocks efflux of Fluconazole (HY-B0101) from a clinical isolate of C. glabrata, but not from a strain lacking the efflux pumps CgCDR1 and PDH1, and reduces the MICs of fluconazole and 4-nitroquinoline 1-oxide in wild-type C. glabrata. It enhances adriamycin-induced inhibition of cell growth, as well as increases the intracellular accumulation of adriamycin and the P-glycoprotein substrate Rhodamine 123 (HY-D0816), in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells in a concentration-dependent manner.

分子量

555.70

Formula

C32H45NO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Milbemycin A4 oxime 相关分类

  • 摩尔计算器

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Keywords:

Milbemycin A4 oxime93074-04-55-Ketomilbemycin A4 oxime 5-Oxomilbemycin A4 5-oximeParasiteInhibitorinhibitorinhibit

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