2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. MM11253

MM11253 是一种有效的选择性 RARγ 拮抗剂，IC50 为 44 nM。 MM11253 对 RARα、RARβ 和 RXRα 的抑制作用较低。MM11253 阻断 RARγ 选择性激动剂的生长抑制作用。

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MM11253 Chemical Structure

MM11253 Chemical Structure

CAS No. : 345952-44-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1020
In-stock
5 mg ￥1000
In-stock
10 mg ￥1600
In-stock
25 mg ￥3500
In-stock
50 mg ￥5500
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

MM11253 相关抗体

Top Publications Citing Use of Products

查看 RAR/RXR 亚型特异性产品:

查看所有亚型
RXRα RXRβ RXRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists[1][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf9 IC50
0.06 μM
Compound: 15b
Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase
Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase
[PMID: 26918322]
Sf9 IC50
1.03 μM
Compound: 15b
Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase
Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase
[PMID: 26918322]
体外研究
(In Vitro)

MM11253 blocks the ability of MM11254 and MM11389 to inhibit squamous cell carcinoma cell growth[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MM11253 相关抗体:
分子量

462.67

Formula

C28H30O2S2
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (270.17 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1614 mL 10.8068 mL 21.6137 mL
5 mM 0.4323 mL 2.1614 mL 4.3227 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MM11253 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1614 mL 10.8068 mL 21.6137 mL 54.0342 mL
5 mM 0.4323 mL 2.1614 mL 4.3227 mL 10.8068 mL
10 mM 0.2161 mL 1.0807 mL 2.1614 mL 5.4034 mL
15 mM 0.1441 mL 0.7205 mL 1.4409 mL 3.6023 mL
20 mM 0.1081 mL 0.5403 mL 1.0807 mL 2.7017 mL
25 mM 0.0865 mL 0.4323 mL 0.8645 mL 2.1614 mL
30 mM 0.0720 mL 0.3602 mL 0.7205 mL 1.8011 mL
40 mM 0.0540 mL 0.2702 mL 0.5403 mL 1.3509 mL
50 mM 0.0432 mL 0.2161 mL 0.4323 mL 1.0807 mL
60 mM 0.0360 mL 0.1801 mL 0.3602 mL 0.9006 mL
80 mM 0.0270 mL 0.1351 mL 0.2702 mL 0.6754 mL
100 mM 0.0216 mL 0.1081 mL 0.2161 mL 0.5403 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM11253345952-44-5MM 11253MM-11253RAR/RXRRetinoic acid receptorsRetinoid X receptorsSelective RARγ antagonistInhibitorinhibitorinhibit

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产品名称：
MM11253
目录号：
HY-108530
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