Momordicoside G  (Synonyms: Momordicacoside G)

Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury^[1].

用 10 ng/mL LPS 或 10 ng/mL IL-10 刺激 Raw264.7 巨噬细胞 24 h，获得 M1 样 (iNOS+) 和 M2样 (精氨酸酶+) 巨噬细胞^[1]。
Momordicoside G (10-40 μM; 24 h) 抑制 M1 巨噬细胞的细胞活力，对 M2 巨噬细胞无抑制作用。 Momordicoside G (40 μM) 体外诱导 M1 巨噬细胞凋亡，降低 NO 水平，增加 IL-12、IL-10 和 TGF-β 水平^[1]。
Momordicoside G (40 μM) 可抑制细胞自噬相关标志物 LC3-B 的蛋白水平^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ICR 小鼠的肺部致癌模型由氨基甲酸乙酯 (HY-B1207) (600 mg/kg；腹腔注射；每周一次，持续 4 或 8 周) 诱导，或由 LPS (HY-D1056) (2 mg/kg；气管内施用) 和 4 mg/小鼠 IEC (腹腔注射) 诱导^[1]。
Momordicoside G (50 mg/kg；口服；每天一次，持续 4 或 8 周) 在小鼠肺致癌模型中可预防氨基甲酸乙酯引起的肺损伤和癌病变^[1]。
Momordicoside G (50 mg/kg；口服；每天一次，持续 2 周) 在 LPS 诱导的肺损伤模型中促进肺损伤修复^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

632.87

C₃₇H₆₀O₈

81371-54-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Du Z, et al. Momordicoside G Regulates Macrophage Phenotypes to Stimulate Efficient Repair of Lung Injury and Prevent Urethane-Induced Lung Carcinoma Lesions. Front Pharmacol. 2019 Mar 29;10:321.  [Content Brief]