1. PROTAC PI3K/Akt/mTOR
  2. PROTACs Akt
  3. MS5033

MS5033 是一种有效的基于 PROTACAKT 降解剂,在 PC3 细胞中的 DC50 值为 430 nM。

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MS5033 Chemical Structure

MS5033 Chemical Structure

CAS No. : 2376137-29-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MS5033 is a potent PROTAC-based AKT (protein kinase B) degrader, with a DC50 of 430 nM in PC3 cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDA-MB-468 GI50
4.8 μM
Compound: 35; , MS5033
Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth by measured after 5 days by IncuCyte zoom live cell analysis
Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth by measured after 5 days by IncuCyte zoom live cell analysis
[PMID: 35119851]
PC-3 GI50
10.8 μM
Compound: 35; , MS5033
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 5 days by IncuCyte zoom live cell analysis
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 5 days by IncuCyte zoom live cell analysis
[PMID: 35119851]
分子量

1044.59

Formula

C51H66ClN11O11

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
MS5033
目录号:
HY-143882
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