2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. MTIC

MTIC  (Synonyms: 替莫唑胺代谢物- MTIC)

目录号: HY-119696 纯度: 99.51%
COA 产品使用指南

摩尔计算器

MTIC 是 Temozolomide (TMZ) 的活性代谢物，是一种 DNA 烷基化剂。MTIC 具有抗肿瘤活性。

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MTIC Chemical Structure

MTIC Chemical Structure

CAS No. : 3413-72-7

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规格 价格 是否有货 数量
5 mg ￥2600
In-stock
10 mg ￥4200
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of MTIC:

MTIC 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity [1][2][3][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SNB-19 GI50
466 μM
Compound: 3; MTIC
Growth inhibition of MGMT-transfected human SNB19 cells after 7 days by MTT assay
Growth inhibition of MGMT-transfected human SNB19 cells after 7 days by MTT assay
10.1039/C6MD00384B
SNB-19 GI50
472 μM
Compound: 2; MTIC
Growth inhibition of MGMT-transfected human SNB19 cells expressing MGMT after 7 days by MTT assay
Growth inhibition of MGMT-transfected human SNB19 cells expressing MGMT after 7 days by MTT assay
[PMID: 30108945]
SNB-19 GI50
48.5 μM
Compound: 3; MTIC
Growth inhibition of empty vector transfected human SNB19 cells after 7 days by MTT assay
Growth inhibition of empty vector transfected human SNB19 cells after 7 days by MTT assay
10.1039/C6MD00384B
SNB-19 GI50
48.5 μM
Compound: 2; MTIC
Growth inhibition of vehicle-transfected human SNB19 cells after 7 days by MTT assay
Growth inhibition of vehicle-transfected human SNB19 cells after 7 days by MTT assay
[PMID: 30108945]
U-373MG ATCC GI50
398 μM
Compound: 3; MTIC
Growth inhibition of MGMT-transfected human U373 cells after 7 days by MTT assay
Growth inhibition of MGMT-transfected human U373 cells after 7 days by MTT assay
10.1039/C6MD00384B
U-373MG ATCC GI50
398 μM
Compound: 2; MTIC
Growth inhibition of MGMT-transfected human U373 cells expressing MGMT after 7 days by MTT assay
Growth inhibition of MGMT-transfected human U373 cells expressing MGMT after 7 days by MTT assay
[PMID: 30108945]
U-373MG ATCC GI50
93.7 μM
Compound: 3; MTIC
Growth inhibition of empty vector transfected human U373 cells after 7 days by MTT assay
Growth inhibition of empty vector transfected human U373 cells after 7 days by MTT assay
10.1039/C6MD00384B
U-373MG ATCC GI50
93.7 μM
Compound: 2; MTIC
Growth inhibition of vehicle-transfected human U373 cells after 7 days by MTT assay
Growth inhibition of vehicle-transfected human U373 cells after 7 days by MTT assay
[PMID: 30108945]
体内研究
(In Vivo)

MTIC (累积剂量=890 mg/大鼠/14 周) 可诱导乳腺腺纤维瘤的高发病率和子宫平滑肌肉瘤的低发病率[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

168.16

Formula

C5H8N6O
CAS 号
性状

固体

颜色

Brown to orange

中文名称

替莫唑胺代谢物- MTIC
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (148.67 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.9467 mL 29.7336 mL 59.4672 mL
5 mM 1.1893 mL 5.9467 mL 11.8934 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MTIC 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.9467 mL 29.7336 mL 59.4672 mL 148.6679 mL
5 mM 1.1893 mL 5.9467 mL 11.8934 mL 29.7336 mL
10 mM 0.5947 mL 2.9734 mL 5.9467 mL 14.8668 mL
15 mM 0.3964 mL 1.9822 mL 3.9645 mL 9.9112 mL
20 mM 0.2973 mL 1.4867 mL 2.9734 mL 7.4334 mL
25 mM 0.2379 mL 1.1893 mL 2.3787 mL 5.9467 mL
30 mM 0.1982 mL 0.9911 mL 1.9822 mL 4.9556 mL
40 mM 0.1487 mL 0.7433 mL 1.4867 mL 3.7167 mL
50 mM 0.1189 mL 0.5947 mL 1.1893 mL 2.9734 mL
60 mM 0.0991 mL 0.4956 mL 0.9911 mL 2.4778 mL
80 mM 0.0743 mL 0.3717 mL 0.7433 mL 1.8583 mL
100 mM 0.0595 mL 0.2973 mL 0.5947 mL 1.4867 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTIC3413-72-7替莫唑胺代谢物- MTICDrug MetaboliteTemozolomidebioavailabilitymetabolitepermeabilitybiological barrierstumor cell membraneaffinityInhibitorinhibitorinhibit

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目录号：
HY-119696
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