2. Cell Cycle/DNA Damage
  3. G-quadruplex
  4. N-Methylmesoporphyrin IX

N-Methylmesoporphyrin IX  (Synonyms: N-甲基中卟啉IX)

目录号: HY-133821 纯度: 97.69%
COA 产品使用指南

摩尔计算器

N-Methylmesoporphyrin IX (NMM) 是一种广泛使用的 G-quadruplex DNA 特异性荧光结合剂，是监测 Aβ 纤颤的有效探针。N-Methylmesoporphyrin IX 是一种原位抑制剂，是体外和细胞内 Aβ 淀粉样蛋白生成的非原位监测器。N-Methylmesoporphyrin IX 对 G-四链体 DNA 敏感，但对双链体、三链体和单链形式的 DNA 没有反应。N-Methylmesoporphyrin IX 单独或在单体 Aβ 环境中不发出荧光，但通过与 Aβ 组装体堆叠发出强荧光。

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N-Methylmesoporphyrin IX Chemical Structure

N-Methylmesoporphyrin IX Chemical Structure

CAS No. : 142234-85-3

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N-Methylmesoporphyrin IX 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies[1].

体外研究
(In Vitro)

By use of N-Methylmesoporphyrin IX (NMM) as an ex situ probe, NMM is added into the incubated Aβ40 solution. The concentration of NMM is fixed at 1μM. To examine the influence of Rhodamine B, 1 μM NMM with 0.1 μM or 0.5 μM Rhodamine B along with 10μM Aβ40 are measured. In the study of using NMM as an in situ inhibitor, NMM (10 μM) is co-incubated with Aβ40 (50 μM) for 7 days at 37 °C. Additional NMM is added before PL measurement to make the concentration of NMM constant (1 μM). The fluorescence spectra of NMM are collected from 550 to 700 nm with an excitation wavelength of 399 nm[1].
N-Methylmesoporphyrin IX (NMM) is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. Upon binding to quadruplex DNA, for efficient π-π stacking, NMM can adjust its macrocycle geometry to match the terminal face of a G-quadruplex, leading to an enhancement in its fluorescence[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N-Methylmesoporphyrin IX 相关抗体:
分子量

580.72

Formula

C35H40N4O4
CAS 号
性状

固体

颜色

Brown to black

中文名称

N-甲基中卟啉IX
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (43.05 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7220 mL 8.6100 mL 17.2200 mL
5 mM 0.3444 mL 1.7220 mL 3.4440 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 97.69%

COA (297 KB) HNMR (273 KB) RP-HPLC (258 KB) LCMS (89 KB)

产品使用指南 (1538 KB)
参考文献

N-Methylmesoporphyrin IX 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7220 mL 8.6100 mL 17.2200 mL 43.0500 mL
5 mM 0.3444 mL 1.7220 mL 3.4440 mL 8.6100 mL
10 mM 0.1722 mL 0.8610 mL 1.7220 mL 4.3050 mL
15 mM 0.1148 mL 0.5740 mL 1.1480 mL 2.8700 mL
20 mM 0.0861 mL 0.4305 mL 0.8610 mL 2.1525 mL
25 mM 0.0689 mL 0.3444 mL 0.6888 mL 1.7220 mL
30 mM 0.0574 mL 0.2870 mL 0.5740 mL 1.4350 mL
40 mM 0.0431 mL 0.2153 mL 0.4305 mL 1.0763 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Methylmesoporphyrin IX142234-85-3N-甲基中卟啉IXG-quadruplexG-quadruplex DNAfluorescent binderAβ fibrillationsituAβ amyloidogenesisduplexestriplexessingle-strandedassembliesInhibitorinhibitorinhibit

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