2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-49

NLRP3-IN-49 (compound Z48) 是一种强效且特异性强的 NLRP3 抑制剂 (在 THP-1 细胞中 IC50=0.26 μM，在小鼠骨髓巨噬细胞中 IC50=0.21 μM)。NLRP3-IN-49 能够直接结合 NLRP3 蛋白 (Kd=1.05 μM)，有效阻止 NLRP3 炎症小体的组装和激活，从而表现出抗炎特性。NLRP3-IN-49 可用于炎症性肠病的研究。

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NLRP3-IN-49 Chemical Structure

NLRP3-IN-49 Chemical Structure

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NLRP3-IN-49 相关抗体

Top Publications Citing Use of Products

查看 NOD-like Receptor (NLR) 亚型特异性产品:

查看所有亚型
NLRP3 NLRP1 NOD1 NOD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NLRP3-IN-49 (compound Z48) is a potent and specific NLRP3 inhibitor (IC50=0.26 μM in THP-1 cells, IC50=0.21 μM in mouse bone marrow macrophages). NLRP3-IN-49 can directly bind to NLRP3 protein (Kd=1.05 μM), effectively preventing the assembly and activation of NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 can be used in the study of inflammatory bowel disease[1].

分子量

491.40

Formula

C22H23BrN2O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NLRP3-IN-49 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-49NOD-like Receptor (NLR)SpecificityinhibitorTHP-1 cellsmouse bone marrow macrophagesinflammasomeanti-inflammatoryInhibitorinhibit

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产品名称：
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目录号：
HY-168089
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