2. Antibody-drug Conjugate/ADC Related JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. Radionuclide-Drug Conjugates (RDCs) EGFR
  4. NODAGA-NHS

NODAGA-NHS  (Synonyms: NODA-GA-NHS ester)

目录号: HY-156991
产品使用指南

摩尔计算器

NODAGA-NHS (NODA-GA-NHS ester) 是一种 [64]Cu 螯合剂，是 DOTA-曲妥珠单抗在体内的解离形式。在 0.1 M 的硼酸缓冲液中，按 5/20/100 等量加入 NODAGA-NHS，能够有效结合曲妥珠单抗 (10 mg/mL) (4°C, 20 h)。其构成的 [64]Cu-NODAGA-曲妥珠单抗的含铜率最高为 80%。对小鼠尾椎静脉抽血后，注射 [64]Cu-NODAGA-曲妥珠单抗，其在表达 HER2 肿瘤的小鼠中，具有良好的肿瘤摄取，显示出良好的 PET 成像示踪能力。

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NODAGA-NHS Chemical Structure

NODAGA-NHS Chemical Structure

CAS No. : 1407166-70-4

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NODAGA-NHS 相关抗体

Top Publications Citing Use of Products

查看 Radionuclide-Drug Conjugates (RDCs) 亚型特异性产品:

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RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

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  • 生物活性

  • 纯度 & 产品资料

生物活性

NODAGA-NHS (NODA-GA-NHS ester) is a [64]Cu chelator and the dissociated form of DOTA-trastuzumab in vivo. NODAGA-NHS was added in 0.1 M borate buffer at a ratio of 5/20/100 and was able to effectively bind trastuzumab (10 mg/mL) (4°C, 20 h). The copper content of the [64]Cu-NODAGA-trastuzumab was up to 80%. After blood was drawn from the caudal vein of mice, [64]Cu-NODAGA-trastuzumab was injected and showed good tumor uptake in mice expressing HER2 tumors, showing good PET imaging tracking ability.

IC50 & Target

RDC Bifunctional Chelator

 

分子量

472.45

Formula

C19H28N4O10
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

NODAGA-NHS 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NODAGA-NHS1407166-70-4NODA-GA-NHS esterRadionuclide-Drug Conjugates (RDCs)EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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