2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Ophiobolin A

Ophiobolin A 是一种真菌代谢产物和植物毒素，是一种有效的、不可逆的钙调素激活环核苷酸磷酸二酯酶的抑制剂，其IC50 值为 9 μM。Ophiobolin A 具有抗菌和抗癌作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Ophiobolin A Chemical Structure

Ophiobolin A Chemical Structure

CAS No. : 4611-05-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2400
In-stock
5 mg 现货 询价
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

Ophiobolin A 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC50 value of 9 μM. Ophiobolin A antimicrobial and anticancer activity[1].

IC50 & Target

IC50: 9 μM (calmodulin-activated cyclic nucleotide phosphodiesterase)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
0.1 μM
Compound: Ophiobolin A
Antiproliferative activity against human A549 cells by MTT assay
Antiproliferative activity against human A549 cells by MTT assay
[PMID: 26341136]
B16-F10 IC50
0.29 μM
Compound: 3
Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 33074690]
Hs 683 GI50
0.02 μM
Compound: Ophiobolin A
Antiproliferative activity against human Hs683 cells by MTT assay
Antiproliferative activity against human Hs683 cells by MTT assay
[PMID: 26341136]
MCF7 GI50
0.06 μM
Compound: Ophiobolin A
Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
[PMID: 26341136]
SK-MEL-28 GI50
0.05 μM
Compound: Ophiobolin A
Antiproliferative activity against human SK-MEL-28 cells by MTT assay
Antiproliferative activity against human SK-MEL-28 cells by MTT assay
[PMID: 26341136]
U-373MG ATCC GI50
0.06 μM
Compound: Ophiobolin A
Antiproliferative activity against human U373 cells by MTT assay
Antiproliferative activity against human U373 cells by MTT assay
[PMID: 26341136]
分子量

400.55

Formula

C25H36O4
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

fungus Bipolaris sp. 
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

Methanol 中的溶解度 : 4 mg/mL (9.99 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4966 mL 12.4828 mL 24.9657 mL
5 mM 0.4993 mL 2.4966 mL 4.9931 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.53%

COA (292 KB) RP-HPLC (463 KB)

产品使用指南 (1538 KB)
参考文献

Ophiobolin A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 2.4966 mL 12.4828 mL 24.9657 mL 62.4142 mL
5 mM 0.4993 mL 2.4966 mL 4.9931 mL 12.4828 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ophiobolin A4611-05-6Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Ophiobolin A
目录号：
HY-N6781
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z