Oxybenzone-d₅  (Synonyms: 氧苯酮-d₅；羟苯酮-d₅；紫外线吸收剂 UV-9-d₅；二苯酮-3-d₅)

Oxybenzone-d₅ is the deuterium labeled Oxybenzone[1]. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells[2][3][4].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

233.27

C₁₄H₇D₅O₃

1219798-54-5

131-57-7

氧苯酮-d₅；羟苯酮-d₅；紫外线吸收剂 UV-9-d₅；二苯酮-3-d₅

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Wnuk A, et al. Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons. J Steroid Biochem Mol Biol. 2018;182:106-118.  [Content Brief]

  [3]. DiNardo JC, et al. Can oxybenzone cause Hirschsprung's disease?. Reprod Toxicol. 201986:98-100.  [Content Brief]

  [4]. Wnuk A, et al. Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells. Mol Neurobiol. 201855(6):5059-5074.  [Content Brief]