2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. PAOPA

PAOPA 是一种 L-脯氨酸-L-亮氨酸-甘氨酸酰胺 (PLG) 肽模拟物，是多巴胺 D2 受体的变构调节剂。PAOPA 可有效减轻精神分裂症啮齿动物模型的行为异常。PAOPA 增加高亲和力多巴胺 D2 受体，促其进激动剂结合而发挥作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PAOPA Chemical Structure

PAOPA Chemical Structure

CAS No. : 114200-31-6

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规格 价格 是否有货 数量
1 mg ￥1800
7 - 9 周
5 mg ￥4500
7 - 9 周
10 mg 现货 7 - 9 周
25 mg 现货 7 - 9 周
50 mg 现货 7 - 9 周
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

PAOPA 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

生物活性

PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of Dopamine D2 Receptor. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine D2 receptor and promotes its binding to agonists[1].

IC50 & Target[1]

D2 Receptor

 

体外研究
(In Vitro)

PAOPA (10 μM; 1.5 h) increases the expression of GRK2 striatum, arrestin-3, phosphorylated ERK1 and ERK2 in D2/eYFP. Cells[1].
PAOPA (10 μM; 48 h) promotes the internalization of D2 receptors in D2/eYFP. Cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PAOPA 相关抗体:
体内研究
(In Vivo)

PAOPA (1 mg/kg; 腹腔注射; 每天 1 次, 共 45 天) 慢性给药, 引起小鼠体内 D2 受体调节和下游分子 (包括 GRK2、arrestin-3 和细胞外受体激酶 ERK 1/2) 的表达增加[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

254.29

Formula

C11H18N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

PAOPA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAOPA114200-31-6Dopamine ReceptorInhibitorinhibitorinhibit

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产品名称：
PAOPA
目录号：
HY-103423
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