2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Perindoprilat

Perindoprilat  (Synonyms: S 9780)

目录号: HY-B1433 纯度: 99.60%
COA 产品使用指南

摩尔计算器

Perindoprilat (S 9780) 是一种血管紧张素转化酶 (ACE) 抑制剂，IC50 值为 1.5-3.2 nM，Perindoprilat 可用于高血压的研究。

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Perindoprilat Chemical Structure

Perindoprilat Chemical Structure

CAS No. : 95153-31-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥495
In-stock
5 mg ￥450
In-stock
10 mg ￥720
In-stock
25 mg ￥1440
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Perindoprilat:

Perindoprilat 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2].

体外研究
(In Vitro)

Perindoprilat (1 μM, 10 days) treatment suppresses the angiotensin II production in HNSCC cells[2]. Perindoprilat (40 μM, 3 days) treatment attenuates mesangial cell fibronectin level[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Perindoprilat 相关抗体:

Cell Viability Assay[2]

Cell Line: HNSCC cells
Concentration: 1 μM
Incubation Time: 10 days
Result: Suppressed the angiotensin II production in HNSCC cells (P=0.028).

Cell Viability Assay[3]

Cell Line: Human mesangial cells
Concentration: 40 μM
Incubation Time: 3 days
Result: Resulted in decreases in MPCM-stimulated fibronectin levels of 19.4±0.6% (P<0.001) and 21.7±1.0% (P<0.001) for secreted and cell-associated fibronectin levels, respectively.
体内研究
(In Vivo)

Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment improves cardiac function in mice with acute myocardial infarction and reduces the number of apoptotic myocardial cells[4].
Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment reduces the expression levels of myocardial Bax and Bcl-2 in infarction zones of mice with acute myocardial infarction[4].
Perindoprilat (oral gavage; 1.5 mg/kg; once daily; 7 d) treatment lowers the expression of myocardial TLR4/NF-κB in infarction zones in mice with acute myocardial infarction[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice underwent coronary ligation[4]
Dosage: 1.5 mg/kg
Administration: Oral gavage; 1.5 mg/kg; once daily; 7 days
Result: Exhibited markedly lowered the number of apoptotic myocardial cells in comparison with the acute myocardial infarction group (p<0.05).
Animal Model: C57BL/6J mice underwent coronary ligation[4]
Dosage: 1.5 mg/kg
Administration: Oral gavage; 1.5 mg/kg; once daily; 7 days
Result: Reduced the gene and protein expression levels of Bax (a myocardial apoptosis gene) in infarction zones in mice with acute myocardial infarction.
Animal Model: C57BL/6J mice underwent coronary ligation[4]
Dosage: 1.5 mg/kg
Administration: Oral gavage; 1.5 mg/kg; once daily; 7 days
Result: Declined the number of stained NF-κB p50 protein in the nucleus in infarction zones (p<0.05), compared to the acute myocardial infarction group.
分子量

340.41

Formula

C17H28N2O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 175 mg/mL (514.09 mM; 超声助溶)

DMSO 中的溶解度 : 100 mg/mL (293.76 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9376 mL 14.6882 mL 29.3763 mL
5 mM 0.5875 mL 2.9376 mL 5.8753 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.60%

COA (199 KB) HNMR (288 KB) RP-HPLC (222 KB) MS (70 KB)

产品使用指南 (1538 KB)
参考文献

Perindoprilat 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.9376 mL 14.6882 mL 29.3763 mL 73.4408 mL
5 mM 0.5875 mL 2.9376 mL 5.8753 mL 14.6882 mL
10 mM 0.2938 mL 1.4688 mL 2.9376 mL 7.3441 mL
15 mM 0.1958 mL 0.9792 mL 1.9584 mL 4.8961 mL
20 mM 0.1469 mL 0.7344 mL 1.4688 mL 3.6720 mL
25 mM 0.1175 mL 0.5875 mL 1.1751 mL 2.9376 mL
30 mM 0.0979 mL 0.4896 mL 0.9792 mL 2.4480 mL
40 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8360 mL
50 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4688 mL
60 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2240 mL
80 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perindoprilat95153-31-4S 9780S9780S-9780Angiotensin-converting Enzyme (ACE)hypertensionACE inhibitorangiotensin-converting enzymeHNSCCInhibitorinhibitorinhibit

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