2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. PF-04634817 succinate

PF-04634817 succinate 

目录号: HY-117621A 纯度: 99.50%
COA 产品使用指南

摩尔计算器

PF-0463481 succinate 是一种有效的具有口服活性的双效 CCR2/CCR5 拮抗剂，对人和啮齿类动物的 CCR2 效价相当 (rat IC50=20.8 nM)，对 CCR2 的效价是 CCR5 的 10-20 倍 (rat IC50=470 nM)。PF-0463481 succinate 安全、耐受性好，有潜力用于研究糖尿病肾病。

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PF-04634817 succinate Chemical Structure

PF-04634817 succinate Chemical Structure

CAS No. : 2140301-98-8

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1170
In-stock
5 mg ￥3105
In-stock
10 mg ￥4950
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of PF-04634817 succinate:

PF-04634817 succinate 相关抗体

Top Publications Citing Use of Products

查看 CCR 亚型特异性产品:

查看所有亚型
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-0463481 succinate is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC50=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC50=470 nM). PF-0463481 succinate is safe and well-tolerated and has the potential for the study of diabetic nephropathy[3].

IC50 & Target[1]

Rat CCR2

20.8 nM (IC50)

CCR5

470 nM (IC50)

体内研究
(In Vivo)

PF-04634817 succinate (oral administration; 30 mg/kg; once daily; 31 days intervention (weeks 2-15 after Streptozotocin )) intervention at the onset of diabetes (week 2) has no impact on the fasting blood glucose levels in diabetic Nos3-/- 221 mice. The development of diabetes results in a marked increase in the levels of glycated haemoglobin (HbA1c) in Nos3-/- mice. Early intervention with PF-04634817 induces an additional increase in glycated hemoglobin (HbA1c) levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nos3-/- mice on the C57BL/6 background[1]
Dosage: 30 mg/kg
Administration: Oral administration; once daily; 31 days intervention (weeks 2-15) after Streptozotocin
Result: Had no impact on the fasting blood glucose levels, but induced an additional increase in HbA1c levels
Clinical Trial
分子量

629.67

Formula

C29H42F3N5O7
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 14.48 mg/mL (23.00 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5881 mL 7.9407 mL 15.8813 mL
5 mM 0.3176 mL 1.5881 mL 3.1763 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.50%

COA (295 KB)

产品使用指南 (1538 KB)
参考文献

PF-04634817 succinate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5881 mL 7.9407 mL 15.8813 mL 39.7033 mL
5 mM 0.3176 mL 1.5881 mL 3.1763 mL 7.9407 mL
10 mM 0.1588 mL 0.7941 mL 1.5881 mL 3.9703 mL
15 mM 0.1059 mL 0.5294 mL 1.0588 mL 2.6469 mL
20 mM 0.0794 mL 0.3970 mL 0.7941 mL 1.9852 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-046348172140301-98-8PF04634817PF 04634817CCRCC chemokine receptorDiabeticMacularEdemaOvertNephropathynon-alcoholicsteatohepatitisNASH,fibrosis,interventionagentInhibitorinhibitorinhibit

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产品名称：
PF-04634817 succinate
目录号：
HY-117621A
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