2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Akt Apoptosis
  4. PI3Kδ-IN-11

PI3Kδ-IN-11 是一种高效且具有选择性的 PI3Kδ 抑制剂，IC50 为 27.5 nM。PI3Kδ-IN-11 剂量依赖性地阻断 PI3K/Akt 通路的活性。PI3Kδ-IN-11 可用于研究 B 细胞或 T 细胞相关的恶性肿瘤。

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PI3Kδ-IN-11 Chemical Structure

PI3Kδ-IN-11 Chemical Structure

CAS No. : 2413257-51-7

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PI3Kδ-IN-11 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC50 value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies[1].

IC50 & Target

PI3Kδ

27.5 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Raji IC50
8.5 μM
Compound: 15c
Antiproliferative activity against human Raji cells assessed as inhibition of cell growth after 48 hrs by MTT assay
Antiproliferative activity against human Raji cells assessed as inhibition of cell growth after 48 hrs by MTT assay
[PMID: 32987316]
Ramos IC50
5.4 μM
Compound: 15c
Antiproliferative activity against human Ramos cells assessed as inhibition of cell growth after 48 hrs by MTT assay
Antiproliferative activity against human Ramos cells assessed as inhibition of cell growth after 48 hrs by MTT assay
[PMID: 32987316]
体外研究
(In Vitro)

PI3Kδ-IN-11 (compound 15c) (0-10 μM; 48 hours) inhibits Raji and Ramos with IC50s of 8.5 μM and 5.4 μM, respectively[1].
PI3Kδ-IN-11 (0.2-15 μM; 0-48 hours) dampens the proliferation of Raji cells in a dose- and time-dependent manner[1].
PI3Kδ-IN-11 (5 μM; 24 hours) triggers 10.78% apoptosis of cells[1].
PI3Kδ-IN-11 (1-1000 nM; 24 hours) dose-dependently reduces the phosphorylation of Akt (S473)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kδ-IN-11 相关抗体:

Cell Viability Assay

Cell Line: Raji and Ramos[1]
Concentration: 0-10 μM
Incubation Time: 48 hours
Result: Inhibited Raji and Ramos with IC50s of 8.5 μM and 5.4 μM, respectively.

Cell Proliferation Assay

Cell Line: Raji[1]
Concentration: 0.2, 1, 4, 8, 10 and 15 μM
Incubation Time: 0, 12, 24, 36, 48 hours
Result: Dampened the proliferation of Raji cells in a dose- and time-dependent manner.

Apoptosis Analysis

Cell Line: Raji[1]
Concentration: 5 μM
Incubation Time: 24 hours
Result: Triggered 10.78% apoptosis of cells.

Western Blot Analysis

Cell Line: Raji[1]
Concentration: 1, 10, 100, 500 and 1000 nM
Incubation Time: 24 hours
Result: Dose-dependently reduced the phosphorylation of Akt (S473), illustrating that the activity of PI3K/Akt pathway was efficiently blocked.
分子量

431.49

Formula

C27H21N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3Kδ-IN-11 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kδ-IN-112413257-51-7PI3KAktApoptosisPhosphoinositide 3-kinasePKBProtein kinase BQuinazoline derivativesMalignanciesPI3K/Akt pathwaySelectivityRaji cellsRamos cellsInhibitorinhibitorinhibit

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