2. Anti-infection
  3. Antibiotic Bacterial Beta-lactamase Penicillin-binding protein (PBP)
  4. Piperacillin hydrate

Piperacillin hydrate  (Synonyms: Pipracil hydrate)

目录号: HY-B1923A
产品使用指南 技术支持

Piperacillin hydrate 是一种半合成的广谱 β-内酰胺类抗生素，通过青霉素结合蛋白具有对革兰阴性菌和部分革兰阳性菌较强的杀菌活性。Piperacillin hydrate 最常与 β-内酰胺酶抑制剂 Tazobactam (HY-B1418) 联合使用。

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Piperacillin hydrate Chemical Structure

Piperacillin hydrate Chemical Structure

CAS No. : 66258-76-2

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Piperacillin hydrate 的其他形式现货产品:

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Other Forms of Piperacillin hydrate:

Piperacillin hydrate 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Metallo-β-lactamase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin hydrate is most commonly used in combination with the β-lactamase inhibitor Tazobactam (HY-B1418)[1][2][3].

体外研究
(In Vitro)

Piperacillin (12.5 μg/mL, 24h) hydrate 对铜绿假单胞菌、粘质沙雷氏菌、大肠埃希菌、克雷伯氏菌和肠杆菌分别有 92%、82%、73%、61% 和 42% 的抑制作用，变形杆菌属大部分对其极敏感。大量接种时 Piperacillin hydrate 不能抑制革兰阴性杆菌的生长 (最低抑菌浓度 > 25 μg/mL) [2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Piperacillin hydrate 相关抗体:
体内研究
(In Vivo)

Piperacillin (100 mg/kg, 静脉注射, 一日四次, 5 天) hydrate 联合 Tazobactam (HY-B1418) (12.5 mg/kg, 静脉注射, 一日四次, 5 天) 可延长肺炎克雷伯菌低接种量小鼠的生存时间[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c low inoculum model of K. pneumoniae, KEN-11 strain[3].
Dosage: 100 mg/kg
Administration: Intravenous injection (i.v.), 4 times a day, 5 d, in combination with Tazobactam (12.5 mg/kg, i.v., 4 times a day, 5 d)
Result: Enabled all mice survived whereas all control mice died by 5 d, decreased the number of bacteria in lungs compared with control group.
Observed no bacteria in the blood of most mice (except for two mice at the early phase) while bacteria were observed in the blood of control group.
Observed few inflammatory cells in the alveoli whereas an influx of numerous inflammatory cells were observed in the control group.
分子量

535.57

Formula

C23H29N5O8S
CAS 号
中文名称

哌拉西林水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Piperacillin hydrate 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Piperacillin66258-76-2Pipracil哌拉西林水合物AntibioticBacterialBeta-lactamasePenicillin-binding protein (PBP)β-lactamasesemisynthetic penicillinbroad spectrumβ-lactam antibioticGram-negative bacteriatazobactamESBL-producingK. pneumoniaeInhibitorinhibitorinhibit

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