Piperacillin sodium  (Synonyms: 哌拉西林钠; Sodium piperacillin)

Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam^[1][2][3].

Piperacillin (12.5 μg/mL, 24h) 对铜绿假单胞菌、粘质沙雷氏菌、大肠埃希菌、克雷伯氏菌和肠杆菌分别有 92%、82%、73%、61% 和 42% 的抑制作用，变形杆菌属大部分对其极敏感。大量接种时 Piperacillin 不能抑制革兰阴性杆菌的生长 (最低抑菌浓度 > 25 μg/ml) ^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Piperacillin (100 mg/kg, 静脉注射, 一日四次, 5 d) 联合 Tazobactam (HY-B1418)(12.5 mg/kg, 静脉注射, 一日四次, 5 d) 可延长肺炎克雷伯菌低接种量小鼠的生存时间^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

539.54

C₂₃H₂₆N₅NaO₇S

59703-84-3

固体

White to off-white

哌拉西林钠

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978，13(3):358-67.  [Content Brief]

  [2]. Bodey GP, et al. Piperacillin: In Vitro Evaluation. Antimicrob Agents Chemother. 1978，14(1):78-87.  [Content Brief]

  [3]. Harada Y, et al. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2014，20(11):O831-9.  [Content Brief]

  [4]. Tan JS, et al. Antipseudomonal penicillins. Med Clin North Am. 1995 Jul;79(4):679-93.  [Content Brief]

  [5]. Lau WK, et al. Randomized, open-label, comparative study of piperacillin-tazobactam administered by continuous infusion versus intermittent infusion for treatment of hospitalized patients with complicated intra-abdominal infection. Antimicrob Agents Chemother. 2006 Nov;50(11):3556-61.  [Content Brief]

  [6]. Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978 Mar;13(3):358-67.  [Content Brief]