2. PROTAC Protein Tyrosine Kinase/RTK Apoptosis
  3. FLT3 VEGFR c-Kit PROTACs FGFR c-Fms Apoptosis PDGFR
  4. Pomalidomide-C5-Dovitinib

Pomalidomide-C5-Dovitinib (compound 2) 是一种含有 Pomalidomide、Dovitinib 并与 CRBN 相连的 PROTAC。Pomalidomide-C5-Dovitinib 对 FLT3-ITD+ AML 细胞具有增强的抗增殖作用。Pomalidomide-C5-Dovitinib 以泛素-蛋白酶体依赖性方式诱导 FLT3-ITD 和 KIT 蛋白降解，并完全阻断其下游信号通路。Pomalidomide-C5-Dovitinib具有研究FLT3-ITD+ 急性髓系白血病的潜力。

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Pomalidomide-C5-Dovitinib Chemical Structure

Pomalidomide-C5-Dovitinib Chemical Structure

CAS No. : 2732969-67-2

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Pomalidomide-C5-Dovitinib 相关抗体

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查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

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PDGFR PDGFRβ PDGFRα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MOLM-13 IC50
9.5 nM
Compound: 2
Antiproliferative activity against human MOLM-13 cells incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human MOLM-13 cells incubated for 48 hrs by CCK-8 assay
[PMID: 34694800]
MV4-11 IC50
9.2 nM
Compound: 2
Antiproliferative activity against human MV4-11 cells incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human MV4-11 cells incubated for 48 hrs by CCK-8 assay
[PMID: 34694800]
分子量

747.77

Formula

C39H38FN9O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pomalidomide-C5-Dovitinib 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-C5-Dovitinib2732969-67-2FLT3VEGFRc-KitPROTACsFGFRc-FmsApoptosisPDGFRCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Vascular endothelial growth factor receptorSCFRCD117Fibroblast growth factor receptorCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RPlatelet-derived growth factor receptorPomalidomideDovitinibCRBNantiproliferativeFLT3-ITDKITubiquitin-proteasome-dependentacute myeloid leukemiaInhibitorinhibitorinhibit

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