2. PROTAC Metabolic Enzyme/Protease
  3. PROTACs Proteasome
  4. PROTAC 20S proteasome subunit β5 degrader 2

PROTAC 20S proteasome subunit β5 degrader 2 

目录号: HY-169135
产品使用指南

摩尔计算器

PROTAC 20S proteasome subunit β5 degrader 2 是一种针对 20S 蛋白酶体亚基 β5 (20S proteasome subunit β5) 的 PROTAC 降解剂，DC50 为 0.16 μM。PROTAC 20S proteasome subunit β5 degrader 2 可抑制癌细胞 FaDu 的增殖，IC50 为 0.23 μM。PROTAC 20S proteasome subunit β5 degrader 2 在小鼠模型中表现出抗肿瘤活性。(粉色：靶蛋白配体 (HY-10227)；蓝色：E3连接酶配体 (HY-103596)；黑色：连接子 (HY-Y1760))

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PROTAC 20S proteasome subunit β5 degrader 2 Chemical Structure

PROTAC 20S proteasome subunit β5 degrader 2 Chemical Structure

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PROTAC 20S proteasome subunit β5 degrader 2 相关抗体

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader for 20S proteasome subunit β5, with a DC50 of 0.16 μM. PROTAC 20S proteasome subunit β5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC50 of 0.23 μM. PROTAC 20S proteasome subunit β5 degrader 2 exhibits antitumor efficacy in mice models[1]. (Pink: Ligand for target protein (HY-10227); Blue: Ligand for E3 ligase (HY-103596); Black: Linker (HY-Y1760))

分子量

845.74

Formula

C46H52BN5O10
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC 20S proteasome subunit β5 degrader 2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC 20S proteasome subunit β5 degrader 2PROTACsProteasomeFaDumultiple myelomaneck squamous cell carcinomaInhibitorinhibitorinhibit

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PROTAC 20S proteasome subunit β5 degrader 2
目录号：
HY-169135
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