1. PROTAC Epigenetics Cell Cycle/DNA Damage
  2. PROTACs PARP
  3. PROTAC PARP1 degrader-1

PROTAC PARP1 degrader-1 (Compound CN0) 是 PARP1PROTAC 降解剂。PROTAC PARP1 degrader-1 激活 cGAS/STING 免疫途径,最终增强 T 细胞对肿瘤细胞的杀伤。PROTAC PARP1 degrader-1 抑制 DNA 损伤修复,导致胞质 DNA 片段高效积累 (蓝色: CRBN 配体,黑色: 连接子;粉色: PARP1 抑制剂)。

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PROTAC PARP1 degrader-1 Chemical Structure

PROTAC PARP1 degrader-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货
1 mg ¥1350
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5 mg ¥3400
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10 mg ¥5500
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC PARP1 degrader-1 (Compound CN0) is a PROTAC degrader of PARP1. PROTAC PARP1 degrader-1 activates the cGAS/STING immunity pathway and eventually enhances T cell killing of tumor cells. PROTAC PARP1 degrader-1 inhibits DNA damage repair, resulting in highly efficient accumulation of cytosolic DNA fragments (Blue: CRBN ligand, Black: linker; Pink: PARP1 inhibitor)[1].

IC50 & Target[1]

PARP-1

 

分子量

576.60

Formula

C32H28N6O5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
PROTAC PARP1 degrader-1
目录号:
HY-158045
需求量: