2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Interferon & Receptors
  5. IFN-alpha
  6. IFN-alpha 5

IFN-alpha 5  (干扰素 α5)

重组蛋白定制服务

干扰素 α5 (IFNA5;IFN-α5) 属于 α / β 干扰素 (IFN) 家族，由巨噬细胞产生，具有抗病毒活性。干扰素 (IFN) 最初被认为是一种“干扰”体外病毒复制的物质。IFN-α/β 及其相关分子被分为 I 型干扰素，其他则分别为 II 型干扰素 (IFN-γ) 和 III 型干扰素 (IFN-λ) 分别[1]。干扰素刺激两种酶的产生:一种蛋白激酶和一种低聚腺苷酸合成酶。而干扰素 α (IFNa) 在各种癌症中显示出显著的生物活性，特别是血液系统恶性肿瘤，如毛细胞白血病和慢性骨髓性白血病[2]。
干扰素 α5 参与先天免疫，是与呼吸道合胞病毒 (RSV) 引起的急性病毒性毛细支气管炎 (AVB) 相关的基因之一，决定 RSV 毛细支气管炎的易感性[3][4]。在流感病毒感染过程中，干扰素 α (IFN-α) 的过度表达可能导致炎症反应失控，引起病理性损伤。然而，干扰素 α5 主要表达于低致病性传染性支气管炎病毒 (IBV)[5]。

IFN-alpha 5 (IFNA5; IFN-α5), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively[1]. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia[2].
IFN-alpha 5 involves in innate immunity, and is one of the genes associated with acute viral bronchiolitis (AVB) caused by respiratory syncytial virus (RSV), determining susceptibility to RSV bronchiolitis[3][4]. The excessively expressed interferon-α (IFN-α) might contribute to the uncontrolled inflammatory responses, causing pathological damage during influenza virus infection. However IFN-alpha 5 is dominantly expressed in respiratory epithelial cells from the patients infected with less pathogenic infectious bronchitis virus (IBV)[5].

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