2. Membrane Transporter/Ion Channel Apoptosis
  3. Sodium Channel Apoptosis
  4. Psalmotoxin 1 TFA

Psalmotoxin 1 TFA  (Synonyms: PcTx1 TFA; Psalmopoeus cambridgei toxin-1 TFA)

目录号: HY-P1411A 纯度: 99.37%
COA 产品使用指南

摩尔计算器

Psalmotoxin 1 (PcTx1) TFA 是一种蛋白质毒素，可与酸敏感离子通道 1a (ASIC1a) 的亚基-亚基界面结合。Psalmotoxin 1 TFA 通过增加 ASIC1a 对 H+ 的表观亲和力 (apparent affinity) 来有效地、选择性抑制 ASIC1a (IC50: 0.9 nM)。Psalmotoxin 1 TFA 可诱导细胞凋亡 (apoptosis)，抑制癌细胞迁移、增殖和侵袭。Psalmotoxin 1 TFA 可用于癌症或神经系统疾病的研究。

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Custom Peptide Synthesis

Psalmotoxin 1 TFA Chemical Structure

Psalmotoxin 1 TFA Chemical Structure

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规格 价格 是否有货 数量
100 μg ￥7000
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Other Forms of Psalmotoxin 1 TFA:

Psalmotoxin 1 TFA 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Psalmotoxin 1 (PcTx1) TFA is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 TFA is a potent and slective ASIC1a inhibitor (IC50: 0.9 nM) by increasing the apparent affinity for H+ of ASIC1a. Psalmotoxin 1 TFA can induce cell apoptosis, also inhibits cell migration, proferliration and invasion of cancer cells. Psalmotoxin 1 TFA can be used in the research of cancers, or neurological disease[1][3][4][6].

体外研究
(In Vitro)

Psalmotoxin 1 (20 nM，125 s) TFA 通过显著改变稳态脱敏曲线以降低 H+ 浓度来抑制 ASIC1a 电流[1]。
Psalmotoxin 1 (30 nM) TFA 与 Ca2+ 竞争结合 ASIC1a 通道[1]。
Psalmotoxin 1 (100 或 200 ng，24-72 小时) TFA 显著减弱 MCF-7 和 MDA-MB-231 细胞的迁移、增殖和侵袭[4]。
Psalmotoxin 1 (100 ng/mL，24 h) 显著抑制酸诱导的增加参与细胞内钙和 LDH 释放，诱导髓核细胞 (NPC) 细胞凋亡和细胞周期停滞[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Psalmotoxin 1 TFA 相关抗体:

Cell Proliferation Assay[4]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 100 or 200 ng
Incubation Time: 24, 48, 72 h
Result: Inhibited the cell migration, proliferation and invasion of breast cancer cells.

Western Blot Analysis[5]

Cell Line: Nucleus pulposus cells (NPCs)
Concentration: 100 ng/mL
Incubation Time: 24 h
Result: Decreased Bax and cleaved caspase-3 expression, and increased Bcl-2 expression.
体内研究
(In Vivo)

Psalmotoxin 1 (icv，1 ng/kg，单次剂量) TFA 通过直接抑制 ASIC1a 在有意识的中风模型中发挥神经保护作用[2]。
Psalmotoxin 1 (尾静脉注射，10 ng/kg，每日一次，持续 7 天) TFA 抑制乳腺癌小鼠模型的肿瘤生长[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneously hypertensive rats (SHR)[2]
Dosage: 1 ng/kg, a single dose.
Administration: Intracerebroventricular (i.c.v.) injection
Result: Reduced cortical and striatal infarct volumes measured 72 h post-stroke.
Reduced the severity of motor deficit at 1 and 3 days after stroke compared to control rats.
Displayed an anti-apoptotic effect in the occluded hemisphere (reduced stroke-induced caspase-3 positive cells).
Animal Model: Female nude BALB/C mice (orthotopic implantation, MCF-7 and MDA-MB-231 cells)[3]
Dosage: 10 ng/kg, daily for 7 days.
Administration: Tail vein injection
Result: Inhibited breast tumor growth.
分子量

4689.39 (free base)

Formula

C200H312N62O57S6.xC2HF3O2
性状

固体

颜色

White to off-white

Sequence

Glu-Asp-Cys-Ile-Pro-Lys-Trp-Lys-Gly-Cys-Val-Asn-Arg-His-Gly-Asp-Cys-Cys-Glu-Gly-Leu-Glu-Cys-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys-Val-Pro-Lys-Thr-Pro-Lys-Thr (Disulfide bridge: Cys3-Cys18, Cys10-Cys23, Cys17-Cys33)
Sequence Shortening

EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (Disulfide bridge: Cys3-Cys18, Cys10-Cys23, Cys17-Cys33)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Psalmotoxin 1 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Psalmotoxin 1PcTx1Psalmopoeus cambridgei toxin-1Psalmotoxin1Psalmotoxin-1PcTx 1PcTx-1Psalmopoeus cambridgei toxin1Psalmopoeus cambridgei toxin 1Sodium ChannelApoptosisNa channelsNa+ channelsSpider toxinhypertensiveneuroprotectionbreast cancerMDA-MB-231MCF-7NPCsapoptosisInhibitorinhibitorinhibit

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目录号：
HY-P1411A
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