2. Cell Cycle/DNA Damage Epigenetics Anti-infection
  3. HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial
  4. Psammaplin A

Psammaplin A 是一种海洋代谢产物，是 HDAC 和 DNA 甲基转移酶 (DNA methyltransferases) 的有效抑制剂。Psammaplin A 是一种高效的选择性 HDAC1 抑制剂，IC50 为 0.9 nM，对 HDAC1 的选择性是 DAC6 的 360 倍，对 HDAC7 和 HDAC8 的效力低 1000 倍以上。Psammaplin A 对革兰氏阳性细菌 (Gram-positive bacteria) 具有抗菌作用，并抑制 DNA 合成和 DNA 促旋酶 (DNA gyrase) 活性。抗肿瘤活性。

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Psammaplin A Chemical Structure

Psammaplin A Chemical Structure

CAS No. : 110659-91-1

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规格 价格 是否有货 数量
100 μg ￥750
In-stock
1 mg ￥1950
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Psammaplin A 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 DNA Methyltransferase 亚型特异性产品:

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DNA Methyltransferase DNMT1 DNMT3 MGMT

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity[1][2].

IC50 & Target

IC50: 0.9 nM (DAC1)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
1.18 μM
Compound: 1, PsA
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 25884112]
A549 IC50
1.76 μM
Compound: PsA
Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay
[PMID: 33636429]
A549 GI50
4.5 μM
Compound: Psammaplin A
Cytotoxicity against human A549 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay
[PMID: 27460171]
A549 GI50
7.5 μM
Compound: 11c
Growth inhibition of human A549 cells after 96 hrs by sulphorhodamine B assay
Growth inhibition of human A549 cells after 96 hrs by sulphorhodamine B assay
[PMID: 22280363]
CHO-K1 EC50
0.9 μM
Compound: 4
Cytotoxicity against CHO-K1 cells by Alamar blue assay
Cytotoxicity against CHO-K1 cells by Alamar blue assay
[PMID: 16962325]
HCT-116 IC50
0.61 μM
Compound: PsA
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
[PMID: 33636429]
HCT-116 IC50
1.62 μM
Compound: 1, PsA
Cytotoxicity against human HCT116 cells by SRB assay
Cytotoxicity against human HCT116 cells by SRB assay
[PMID: 25884112]
HeLa IC50
0.05 μM
Compound: Psammaplin A
Inhibition of HDAC in human HeLa cells using Fluor deLys as substrate assessed as deacetylation of substrate by fluorescence assay
Inhibition of HDAC in human HeLa cells using Fluor deLys as substrate assessed as deacetylation of substrate by fluorescence assay
[PMID: 27460171]
HL-60 GI50
0.29 μM
Compound: Psammaplin A
Cytotoxicity against human HL60 cells assessed as reduction in cell growth inhibition after 72 hrs by trypan blue-staining based hemocytometric analysis
Cytotoxicity against human HL60 cells assessed as reduction in cell growth inhibition after 72 hrs by trypan blue-staining based hemocytometric analysis
[PMID: 27460171]
HL-60 GI50
0.37 μM
Compound: 1; PsA
Growth inhibition of human HL-60 cells after 72 hrs by trypan blue dye based assay
Growth inhibition of human HL-60 cells after 72 hrs by trypan blue dye based assay
[PMID: 33488962]
MCF7 GI50
1.27 μM
Compound: 11c
Growth inhibition of human MCF7 cells after 96 hrs by sulphorhodamine B assay
Growth inhibition of human MCF7 cells after 96 hrs by sulphorhodamine B assay
[PMID: 22280363]
MCF7 GI50
2.26 μM
Compound: Psammaplin A
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay
[PMID: 27460171]
MCF7 IC50
5 μM
Compound: 1
Antiproliferative activity against human MCF7 cells by neutral red method
Antiproliferative activity against human MCF7 cells by neutral red method
[PMID: 16643023]
MCF7 EC50
5.7 μM
Compound: 1
Activation of PPARgamma transfected in human MCF7 cells by luciferase reporter gene assay
Activation of PPARgamma transfected in human MCF7 cells by luciferase reporter gene assay
[PMID: 16643023]
MDA-MB-231 IC50
1.31 μM
Compound: PsA
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability by SRB assay
[PMID: 33636429]
PC-3 GI50
3.52 μM
Compound: Psammaplin A
Cytotoxicity against human PC3 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as reduction in cell growth inhibition after 96 hrs by MTT assay
[PMID: 27460171]
SK-HEP1 IC50
1.29 μM
Compound: PsA
Cytotoxicity against human SK-HEP1 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human SK-HEP1 cells assessed as reduction in cell viability by SRB assay
[PMID: 33636429]
SNU-638 IC50
0.56 μM
Compound: PsA
Cytotoxicity against human SNU-638 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human SNU-638 cells assessed as reduction in cell viability by SRB assay
[PMID: 33636429]
T-cell EC50
0.2 μM
Compound: Psammaplin A
Reactivation of latent HIV1 NL4-3-Luc expression in human naive CD4+ T cells treated 7 days post-infection measured after 48 hrs by luminescence plate reader analysis
Reactivation of latent HIV1 NL4-3-Luc expression in human naive CD4+ T cells treated 7 days post-infection measured after 48 hrs by luminescence plate reader analysis
[PMID: 24495105]
WI-38 GI50
3.44 μM
Compound: 11c
Growth inhibition of human WI38 cells after 96 hrs by sulphorhodamine B assay
Growth inhibition of human WI38 cells after 96 hrs by sulphorhodamine B assay
[PMID: 22280363]
分子量

664.39

Formula

C22H24Br2N4O6S2
CAS 号
性状

固体

颜色

Off-white to yellow

结构分类
初始来源

marine sponge
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 33.3 mg/mL (50.12 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5051 mL 7.5257 mL 15.0514 mL
5 mM 0.3010 mL 1.5051 mL 3.0103 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥96.0%

COA (167 KB) 元素分析报告 (206 KB)

产品使用指南 (1538 KB)
参考文献

Psammaplin A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5051 mL 7.5257 mL 15.0514 mL 37.6285 mL
5 mM 0.3010 mL 1.5051 mL 3.0103 mL 7.5257 mL
10 mM 0.1505 mL 0.7526 mL 1.5051 mL 3.7629 mL
15 mM 0.1003 mL 0.5017 mL 1.0034 mL 2.5086 mL
20 mM 0.0753 mL 0.3763 mL 0.7526 mL 1.8814 mL
25 mM 0.0602 mL 0.3010 mL 0.6021 mL 1.5051 mL
30 mM 0.0502 mL 0.2509 mL 0.5017 mL 1.2543 mL
40 mM 0.0376 mL 0.1881 mL 0.3763 mL 0.9407 mL
50 mM 0.0301 mL 0.1505 mL 0.3010 mL 0.7526 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Psammaplin A110659-91-1HDACDNA MethyltransferaseDNA/RNA SynthesisBacterialHistone deacetylasesDNMTsDNA MTasesHDAC1antitumormarinemetabolitepigeneticoximecytotoxicityantimicrobiaDNAgyraseInhibitorinhibitorinhibit

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目录号：
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