2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. Radionuclide-Drug Conjugates (RDCs) PSMA
  4. PSMA-D5

PSMA-D5 对 PSMA 有结合亲和力，Ki 为 0.21 nM，在进行放射性标记后可用于 PSMA 示踪。PSMA-D5 ([68Ga] 标记) 含有 DOTA 螯合剂，允许 177Lu 和 225Ac 等治疗性放射性核素方便地标记。PSMA-D5 ([68Ga] 标记) 显示出卓越的药代动力学特性，在 22Rv1 肿瘤中表现出显著的肿瘤摄取率。PSMA-D5 可用于放射性核素偶联药物 (RDC) 的合成/研究。

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Custom Peptide Synthesis

PSMA-D5 Chemical Structure

PSMA-D5 Chemical Structure

CAS No. : 3056440-83-3

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PSMA-D5 相关抗体

Top Publications Citing Use of Products

查看 Radionuclide-Drug Conjugates (RDCs) 亚型特异性产品:

查看所有亚型
RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PSMA-D5 has a binding affinity for PSMA with Ki of 0.21 nM and can be used for PSMA tracing after radiolabeling. PSMA-D5 ([68Ga]-labeled) contains a DOTA chelator, allowing convenient labeling with therapeutic radionuclides such as 177Lu and 225Ac. PSMA-D5 ([68Ga]-labeled) shows excellent pharmacokinetic properties, exhibiting remarkable tumor uptake in 22Rv1 tumors[1]. PSMA-D5 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

体外研究
(In Vitro)

PSMA-D5 ([68Ga] 标记) (1 h) 在 PSMA 阳性的 22Rv1 细胞中表现出卓越的摄取性能 (摄取值：1.68) [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PSMA-D5 相关抗体:
体内研究
(In Vivo)

PSMA-D5 ([68Ga] 标记) (∼3.7 MBq，静脉注射) 在 22Rv1 肿瘤中显示出高的肿瘤摄取率（SUVmax = 3.51），与 PSMA-11 ([68Ga] 标记) 相比 (T/M 值分别为 32.01 和 26.8)，能更好地显示较小的病灶。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1317.31

Formula

C57H80N12O24
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PSMA-D5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSMA-D53056440-83-3Radionuclide-Drug Conjugates (RDCs)PSMAProstate-specific membrane antigenProstate cancer22Rv1BALB/cPETStability.Inhibitorinhibitorinhibit

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