2. 多肽产品
  3. 多肽及其衍生物
  4. 多肽药物递送
  5. 多肽偶联物
  6. Pt(IV)-M13

Pt(IV)-M13 是一种能透过血脑屏障的铂 (IV) 前药与全氟芳基大环肽偶联物。Pt(IV)-M13 对神经胶质瘤干细胞具有细胞毒性，能够提高铂在脑内的摄取。Pt(IV)-M13 可用于胶质母细胞瘤的研究。

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Custom Peptide Synthesis

Pt(IV)-M13 Chemical Structure

Pt(IV)-M13 Chemical Structure

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Customer Review

Pt(IV)-M13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pt(IV)-M13 is a BBB-penatrable Platinum (IV) prodrug-perfluoroaryl macrocyclic peptide conjugate. Pt(IV)-M13 is cytotoxic to glioma stem cells and increases uptake of platinum in the brain. Pt(IV)-M13 can be used in the study of glioblastoma[1].

体外研究
(In Vitro)

Pt(IV)-M13 (1-30 μM；80 小时) 对 G9 神经球的 IC50 约为 5 μM，与顺铂 (HY-17394) 相似[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pt(IV)-M13 相关抗体:
体内研究
(In Vivo)

Pt(IV)-M13 (2.5 mg/kg；尾静脉注射；单剂量) 可在小鼠中显著增加到达大脑的铂含量，比顺铂 (HY-17394) 高 15 倍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2947.63

Formula

C120H190ClF8N30O28PtS2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pt(IV)-M13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pt(IV)-M13Inhibitorinhibitorinhibit

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