2. PROTAC Apoptosis
  3. PROTACs Bcl-2 Family
  4. PZ703b

PZ703b 是一种 Bcl-xl PROTAC 降解剂，可诱导细胞凋亡 (apoptosis)，抑制癌细胞增殖。PZ703b 可用于膀胱癌研究。

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PZ703b Chemical Structure

PZ703b Chemical Structure

CAS No. : 2471970-56-4

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规格 价格 是否有货 数量
1 mg ￥9800
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Customer Review

Other Forms of PZ703b:

PZ703b 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research[1][2].

IC50 & Target

VHL

 

Bcl-xL

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MOLT-4 IC50
15.9 nM
Compound: PZ703b
Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 34533954]
Platelet IC50
0.95 μM
Compound: PZ703b
Cytotoxicity against platelets in human PRP assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against platelets in human PRP assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 34533954]
RS4-11 IC50
11.3 nM
Compound: PZ703b
Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 34533954]
RS4-11 IC50
209 nM
Compound: PZ703b
Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs in presence of VHL-032 by MTS assay
Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs in presence of VHL-032 by MTS assay
[PMID: 34533954]
体外研究
(In Vitro)

PZ703b (0-1 μM, 24 h) 与 Mivebresib 协同抑制膀胱癌细胞增殖，并通过线粒体通路诱导膀胱癌细胞凋亡[1]。
PZ703b (0-1 μM, 48 h) 抑制 MOLT-4 和 RS4;11 的细胞活性 IC50 值分别为 15.9 和 11.3 nM[2]。
PZ703b hydrochloride (10 nM, 48 h) 通过 caspase-3 介导的通路诱导 MOLT-4 细胞凋亡和 BCL-XL 的降解[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PZ703b 相关抗体:

Cell Viability Assay[1]

Cell Line: MOLT-4 cell line
Concentration: 10 nM
Incubation Time: 48 hours
Result: Induced cell apoptosis of MOLT-4 cells.
分子量

1600.43

Formula

C80H102ClF3N10O11S4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (62.48 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6248 mL 3.1242 mL 6.2483 mL
5 mM 0.1250 mL 0.6248 mL 1.2497 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

PZ703b 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6248 mL 3.1242 mL 6.2483 mL 15.6208 mL
5 mM 0.1250 mL 0.6248 mL 1.2497 mL 3.1242 mL
10 mM 0.0625 mL 0.3124 mL 0.6248 mL 1.5621 mL
15 mM 0.0417 mL 0.2083 mL 0.4166 mL 1.0414 mL
20 mM 0.0312 mL 0.1562 mL 0.3124 mL 0.7810 mL
25 mM 0.0250 mL 0.1250 mL 0.2499 mL 0.6248 mL
30 mM 0.0208 mL 0.1041 mL 0.2083 mL 0.5207 mL
40 mM 0.0156 mL 0.0781 mL 0.1562 mL 0.3905 mL
50 mM 0.0125 mL 0.0625 mL 0.1250 mL 0.3124 mL
60 mM 0.0104 mL 0.0521 mL 0.1041 mL 0.2603 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PZ703b2471970-56-4PROTACsBcl-2 FamilyPROTACapoptosiscancerbladder cancerMOLT-4RS4;11Inhibitorinhibitorinhibit

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产品名称：
PZ703b
目录号：
HY-115718
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