QAQ 

QAQ dichloride dichloride, a photoswitchable voltage-gated Na_v and K_v channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain^[1][2].

Target: voltage-gated Na_v and K_v channels

QAQ dichloride dichloride (100 μM) does not cross the membrane and can be injected into cells through a micropipette to photosensitize a single cell and afford subcellular control of action potential propagation. It blocks Shaker-IR current in the trans configuration and unblocks it in the cis configuration^[1].
QAQ dichloride dichloride can be used to develop red-shifted derivatives of QAQ dichloride, powerful doubly charged photochromic blockers.These derivatives allow for remote control of K_v and Na_v channel conductance with light and offer the opportunity to silence neuronal activity reversibly^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

496.69

C₂₈H₄₄N₆O₂²⁺

1204416-85-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Timm Fehrentz, et al. Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers. Chembiochem. 2012 Aug 13;13(12):1746-9.  [Content Brief]

  [2]. Alexandre Mourot, et al.Photochromic Potassium Channel Blockers: Design and Electrophysiological Characterization. Methods Mol Biol. 2013;995:89-105.  [Content Brief]